Evidence map›Paper›PMID 28808000›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Brian T Ho, Yang Fu, Tao G Dong, John J Mekalanos

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Bacterial warfare at the molecular level:Current research in microbial sciences · 2026
    Article
  3. The SPI-20 and SPI-21 T6SS gene clusters fromFrontiers in microbiology · 2026
    Article
  4. Article
  5. Article
  6. Dissecting the antibacterial functions of the T6SS-2 cluster inApplied and environmental microbiology · 2025
    Article
  7. Deciphering theJournal of bacteriology · 2025
    Review
  8. Article
  9. Review
  10. Mobile-CRISPRi as a powerful tool for modulatingApplied and environmental microbiology · 2024
    Article
  11. Article
  12. Article
  13. Genomic analysis ofFrontiers in microbiology · 2024
    Article
  14. ToxigenicApplied and environmental microbiology · 2023
    Article
  15. Article
  16. Article
  17. Pesticin-Like Effector VgrG3Microbiology spectrum · 2023
    Article
  18. International journal of molecular sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Brian T HoDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Yang FuDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Tao G DongDepartment of Ecosystem and Public Health, University of Calgary, Calgary, AB T2N 1N4 Canada.
John J MekalanosDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; john_mekalanos@hms.harvard.edu.
Harvard University · USUniversity of Calgary · CA

Funding

Genetic analysis of toxinogenesis of Vibrio choleraeR37AI018045 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI John Joseph Mekalanos · 1989 to 2026
$12.8M
Genetic Analysis of Toxinogenesis in Vibrio CholeraeR01AI018045 · NIAID · HARVARD MEDICAL SCHOOL · PI MEKALANOS, JOHN JOSEPH · 2009 to 2018
$6.7M
NIAID NIH HHS R37 AI018045
6 · The paper itself

Abstract

The type 6 secretion system (T6SS) is used by many Gram-negative bacterial species to deliver toxic effector proteins into nearby bacteria prey cells to kill or inhibit their growth. VgrG proteins are core conserved secretion substrates of the T6SS and one subset of T6SS effectors consists of VgrG proteins with C-terminal extension domains carrying various enzymatic activities. In

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialProtein TransportType VI Secretion SystemsVibrio choleraeBacterial ProteinsType VI Secretion Systemseffector engineeringeffector traffickinginterbacterial competitiontype 6 secretion systemVgrG

Identifiers

PMID28808000
PMCPMC5584461
OpenAlexW2749658709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.