Evidence map›Paper›PMID 28807982›Full record

ArticleBlood2017

C/EBPβ is required for survival of Ly6C

Akihiro Tamura, Hideyo Hirai, Asumi Yokota, Naoka Kamio, Atsushi Sato, Tsukimi Shoji, Takahiro Kashiwagi, Yusuke Torikoshi, Yasuo Miura, Daniel G Tenen and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 81 citations in OpenAlex.

  1. Transcriptional regulation and function of GPR18 in macrophage subtype specification.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. metileneNature communications · 2026
    Article
  4. Integrated Single-Cell Multi-Omics Analysis Reveals That a CD8International journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Modulation of Septic Shock: A Proteomic Approach.International journal of molecular sciences · 2024
    Article
  12. Article
  13. Novel Long Noncoding RNACirculation · 2024
    Article
  14. Article
  15. Transcription factor C/EBPα is required for the development of Ly6CProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. NanoSHP099-Targeted SHP2 Inhibition Boosts Ly6CAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Akihiro TamuraDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Hideyo HiraiDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Asumi YokotaDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Naoka KamioDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Atsushi SatoDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Tsukimi ShojiDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Takahiro KashiwagiDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Yusuke TorikoshiDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Yasuo MiuraDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Daniel G TenenCancer Science Institute, National University of Singapore, Singapore; and.
Taira MaekawaDepartment of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
Kyoto University Hospital · JPHarvard Stem Cell Institute · US

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6M
Mechanisms of regulation by RNA in acute myeloid leukemiaR35CA197697 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2021
$7.1M
NCI NIH HHS P01 CA066996NCI NIH HHS R35 CA197697NHLBI NIH HHS P01 HL131477
6 · The paper itself

Abstract

The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) is highly expressed in monocytes/macrophages. However, its roles in monopoiesis are largely unknown. Here, we investigated the roles of C/EBPβ in monopoiesis. Further subdivision of monocytes revealed that

Indexed as

AnimalsAntigens, LyApoptosisCCAAT-Enhancer-Binding Protein-betaCell DifferentiationCells, CulturedCell SurvivalChlorocebus aethiopsCOS CellsGene Expression RegulationMiceMice, KnockoutMonocytesReceptors, Granulocyte-Macrophage Colony-Stimulating FactorAntigens, LyCCAAT-Enhancer-Binding Protein-betaCsf1r protein, mouseLy-6C antigen, mouseReceptors, Granulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID28807982
PMCPMC5649551
OpenAlexW2747823021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.