Evidence map›Paper›PMID 28807923›Full record

ArticleAntimicrobial agents and chemotherapy2017

PBP4 Mediates β-Lactam Resistance by Altered Function.

Som S Chatterjee, Liang Chen, Aubre Gilbert, Thaina M da Costa, Vinod Nair, Sandip K Datta, Barry N Kreiswirth, Henry F Chambers

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Genetic Variation in theAntibiotics (Basel, Switzerland) · 2025
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  7. eLife · 2024
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  8. Structural Insights into the Penicillin-Binding Protein 4 (DacB) fromInternational journal of molecular sciences · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Identification ofAntibiotics (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Article
  16. Mutations in theMicrobial genomics · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Constructing and deconstructing the bacterial cell wall.Protein science : a publication of the Protein Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Som S ChatterjeeDivision of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA som.chatterjee@ucsf.edu.
Liang ChenPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Aubre GilbertDivision of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA.
Thaina M da CostaDivision of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA.
Vinod NairMicroscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Sandip K DattaBacterial Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Barry N KreiswirthPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Henry F ChambersDivision of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA.
San Francisco General Hospital · USRutgers, The State University of New Jersey · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USUniversity of California, San Francisco · US

Funding

Novel Mechanisms of Beta-lactam Resistance in Staph AureusR01AI100291 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2013 to 2023
$5.1M
NIAID NIH HHS R01 AI100291
6 · The paper itself

Abstract

Penicillin binding protein 4 (PBP4) can provide high-level β-lactam resistance in

Indexed as

Anti-Bacterial Agentsbeta-Lactam ResistanceGenome, BacterialMutation, MissensePenicillin-Binding ProteinsPenicillinsPromoter Regions, GeneticStaphylococcus aureusAnti-Bacterial AgentsPenicillin-Binding ProteinsPenicillinsPBP4Staphylococcus aureusβ-lactam resistance

Identifiers

PMID28807923
PMCPMC5655059
OpenAlexW2750014010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.