Evidence map›Paper›PMID 28807915›Full record

Trial reportAntimicrobial agents and chemotherapy2017

A Randomized Controlled Trial Shows that both 14-Day Hybrid and Bismuth Quadruple Therapies Cure Most Patients with Helicobacter pylori Infection in Populations with Moderate Antibiotic Resistance.

Feng-Woei Tsay, Deng-Chyang Wu, Hsien-Chung Yu, Sung-Shuo Kao, Kung-Hung Lin, Jin-Shiung Cheng, Huay-Min Wang, Wen-Chi Chen, Wei-Chih Sun, Kuo-Wang Tsai and 1 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07146594 (Clinical Evaluation of a 14day Modified Bismuth Quadruple Therapy for the Eradication of H. Pylori in a High Clarithromycin and Metronidazole Resistance Area), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07146594 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Evaluation of a 14day Modified Bismuth Quadruple Therapy for the Eradication of H. Pylori in a High Clarithromycin and Metronidazole Resistance Area

TypeinterventionalSponsorAthens Medical CenterRan2025 to 2026Enrolled150ConditionsHelicobacter Pylori Gastritis, Helicobacter EradicationArmsModified bismuth-containing eradication treatment
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Novel therapeutic regimens againstFrontiers in microbiology · 2024
    Review
  8. Article
  9. Article
  10. Update on the first-line treatment ofTherapeutic advances in gastroenterology · 2022
    Review
  11. Article
  12. Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
    Article
  13. Therapeutic advances in gastroenterology · 2021
    Review
  14. Article
  15. Article
  16. BestAntibiotics (Basel, Switzerland) · 2020
    Review
  17. Article
  18. Trend of changes in antibiotic resistance inTherapeutic advances in gastroenterology · 2020
    Article
  19. Article
  20. Update on the first-line treatment forBiomarker research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Feng-Woei TsayDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0002-8934-5464
Deng-Chyang WuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Hsien-Chung YuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
Sung-Shuo KaoDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
Kung-Hung LinDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
Jin-Shiung ChengDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
Huay-Min WangDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
Wen-Chi ChenDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0002-7572-4201
Wei-Chih SunDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
Kuo-Wang TsaiDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Ping-I HsuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan williamhsup@yahoo.com.tw.
National Yang Ming Chiao Tung University · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWKaohsiung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hybrid therapy is a novel two-step treatment achieving a high eradication rate for

Indexed as

2-PyridinylmethylsulfinylbenzimidazolesAmoxicillinClarithromycinDrug Administration ScheduleDrug Resistance, BacterialDrug Therapy, CombinationFemaleHelicobacter InfectionsHelicobacter pyloriHumansMaleMetronidazoleMiddle AgedOrganometallic CompoundsPantoprazoleProspective Studies2-PyridinylmethylsulfinylbenzimidazolesAmoxicillinbismuth tripotassium dicitrateClarithromycinMetronidazoleOrganometallic CompoundsPantoprazoleTetracyclineantibiotic resistancebismuth quadruple therapyHelicobacter pylorihybrid therapy

Identifiers

PMID28807915
PMCPMC5655074
OpenAlexW2746975214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.