Observational studyAntimicrobial agents and chemotherapy2017
Amplification of Antimicrobial Resistance in Gut Flora of Patients Treated with Ceftriaxone.
Observational study in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Cefdinir Versus Cephalexin for the Treatment of Uncomplicated Urinary Tract Infections.Open forum infectious diseases · 2025Trial
- Trial
- Estimating treatment effects from non-overlapping cohorts with application to antimicrobial resistance.BMC medical research methodology · 2026Article
- Unraveling Ceftriaxone Dosing: Free Drug Prediction, Threshold Optimization, and Model Validation.The AAPS journal · 2025Article
- Antimicrobial prescribing quality in Australian emergency departments: an analysis of the Hospital NAPS data set.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Impact of Bacillus licheniformis from yaks following antibiotic therapy in mouse model.Applied microbiology and biotechnology · 2024Article
- Adverse Events Comparison of Double Beta-Lactam Combinations for Bloodstream Infections: Ampicillin plus Ceftriaxone and Ampicillin/Cloxacillin.Antibiotics (Basel, Switzerland) · 2024Article
- The Effects of Ceftriaxone on Glutamate Transporter Expression and the Gut Microbiome: Implications for a Role of Antibiotic-Induced Dysbiosis in Mediating Drug Seeking and Relapse.Gut microbes reports · 2024Article
- Validating a novel three-times-weekly post-hemodialysis ceftriaxone regimen in infected Indigenous Australian patients-a population pharmacokinetic study.The Journal of antimicrobial chemotherapy · 2023Article
- Can precision antibiotic prescribing help prevent the spread of carbapenem-resistant organisms in the hospital setting?JAC-antimicrobial resistance · 2023Review
- Article
- Gut Microbiota Modulation and Prevention of Dysbiosis as an Alternative Approach to Antimicrobial Resistance: A Narrative Review.The Yale journal of biology and medicine · 2022Review
- Comparison of the global prevalence and trend of human intestinal carriage of ESBL-producingJAC-antimicrobial resistance · 2022Review
- Murine Model for Measuring Effects of Humanized-Dosing of Antibiotics on the Gut Microbiome.Frontiers in microbiology · 2022Article
- Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance.eLife · 2020Observational
- Impact of antimicrobial therapy on the gut microbiome.The Journal of antimicrobial chemotherapy · 2019Review
- [S2k guidelines of the PEG on calculated parenteral initial treatment of bacterial diseases in adults : Focussed summary and supplementary information on antibiotic treatment of critically ill patients].Der Anaesthesist · 2018Review
- Ecological effects of cefepime use during antibiotic cycling on the Gram-negative enteric flora of ICU patients.Intensive care medicine experimental · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although antibacterial therapy has an impact on human intestinal flora and the emergence of resistant bacteria, its role in the amplification of antimicrobial resistance and the quantitative exposure-effect relationship is not clear. An observational prospective study was conducted to determine whether and how ceftriaxone exposure is related to amplification of resistance in non-intensive care unit (non-ICU) patients. Serial stool samples from 122 extended-spectrum β-lactamase-positive (ESBL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.