Evidence map›Paper›PMID 28807841›Full record

ReviewGastroenterology2017

Racial Disparity in Gastrointestinal Cancer Risk.

Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers

Open access · bronzeAbstract readReview
In one paragraph

Review in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 3 syntheses or guidelines pooled it, 252 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  8. SOMATIC MUTATION PROFILES IN COLORECTAL CANCERS DIFFER BY POPULATION.medRxiv : the preprint server for health sciences · 2026
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hassan AshktorabDepartment of Medicine, Howard University, Washington, District of Columbia; Cancer Center, Howard University, Washington, District of Columbia.
Sonia S KupferSection of Gastroenterology, Department of Medicine, University of Chicago, Chicago, Illinois.
Hassan BrimDepartment of Pathology, Howard University, Washington, District of Columbia.
John M CarethersDivision of Gastroenterology, Department of Internal Medicine, Department of Human Genetics and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan. Electronic address: jcarethe@umich.edu.
Howard University · USUniversity of Chicago · USUniversity of Michigan–Ann Arbor · US

Funding

PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
MICROSATELLITE INSTABILITY &DNA MISMATCH REPAIR SYSTEMR01DK067287 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARETHERS, JOHN M · 2005 to 2015
$3.2M
(PQ3) Immune Modulation of DNA Mismatch Repair in Colorectal CancerR01CA206010 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARETHERS, JOHN M · 2016 to 2020
$1.8M
Inflammatory Differentiation of Colorectal Cancer Among African AmericansU01CA162147 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARETHERS, JOHN M · 2012 to 2016
$1.4M
Genetic Association Studies in African American Colorectal Cancer PatientsK08CA142892 · NCI · UNIVERSITY OF CHICAGO · PI KUPFER, SONIA · 2010 to 2014
$822k
NCI NIH HHS K08 CA142892NCI NIH HHS R01 CA206010NCI NIH HHS U01 CA162147NIDDK NIH HHS R01 DK067287NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

Cancer from the gastrointestinal tract and its associated excretory organs will occur in more than 300,000 Americans in 2017, with colorectal cancer responsible for >40% of that burden; there will be more than 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to the incidence and mortality of these cancers exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in non-Hispanic whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among blacks. Liver cancer has been most frequent among Asian/Pacific Islanders, chiefly due to hepatitis B vertical transmission, but other racial groups show increasing rates due to hepatitis C and emergence of cirrhosis from non-alcoholic fatty liver disease. Gastric cancer incidence remains highest among Asian/Pacific Islanders likely due to gene-environment interaction. In addition to esophageal squamous cell carcinoma, cancers of the small bowel, pancreas, and colorectum show the highest rates among blacks, where the explanations for the disparity are not as obvious and are likely multifactorial, including socioeconomic and health care access, treatment, and prevention (vaccination and screening) differences, dietary and composition of the gut microbiome, as well as biologic and genetic influences. Cognizance of these disparities in gastrointestinal cancer risk, as well as approaches that apply precision medicine methods to populations with the increased risk, may reduce the observed disparities for digestive cancers.

Indexed as

Health Status DisparitiesRacial GroupsDigestive System NeoplasmsFemaleHumansIncidenceLife StyleMalePrognosisRisk AssessmentRisk FactorsSex DistributionTime FactorsUnited StatesAfrican AmericanAnal CancerCancer DisparityCancer EpidemiologyCancer RiskColorectal CancerEsophageal CancerGastric CancerHepatocellular CarcinomaPancreatic CancerRacial DisparitySmall Bowel Cancer

Identifiers

PMID28807841
PMCPMC5623134
OpenAlexW2742947852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.