ReviewNeuroscience and biobehavioral reviews2018
A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome.The Journal of clinical endocrinology and metabolism · 2024Article
- Experimental Medicine Approaches in Early-Phase CNS Drug Development.Advances in neurobiology · 2023Article
- [Complex regional pain syndrome-An update].Schmerz (Berlin, Germany) · 2022Article
- Childhood maltreatment and its role in the development of pain and psychopathology.The Lancet. Child & adolescent health · 2022Review
- Complex Regional Pain Syndrome or Limb Pain: A Plea for a Critical Approach.Journal of pain research · 2022Article
- The neurobiology of childhood trauma, from early physical pain onwards: as relevant as ever in today's fractured world.European journal of psychotraumatology · 2022Review
- [Complex regional pain syndrome-An update].Der Nervenarzt · 2021Article
- A multidisciplinary assessment of pain in juvenile idiopathic arthritis.Seminars in arthritis and rheumatism · 2021Article
- Pain Phenotypes in Rare Musculoskeletal and Neuromuscular Diseases.Neuroscience and biobehavioral reviews · 2021Review
- Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva.Orphanet journal of rare diseases · 2021Article
- Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography.Pain · 2019Article
- Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.Nature reviews. Neurology · 2018Review
- The role of fMRI in drug development.Drug discovery today · 2018Review
- Complex regional pain syndrome-up-to-date.Pain reports · 2017Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Assessing clinical pain and metrics related to function or quality of life predominantly relies on patient reported subjective measures. These outcome measures are generally not applicable to the preclinical setting where early signs pointing to analgesic value of a therapy are sought, thus introducing difficulties in animal to human translation in pain research. Evaluating brain function in patients and respective animal model(s) has the potential to characterize mechanisms associated with pain or pain-related phenotypes and thereby provide a means of laboratory to clinic translation. This review summarizes the progress made towards understanding of brain function in clinical and preclinical pain states elucidated using an imaging approach as well as the current level of validity of translational pain imaging. We hypothesize that neuroimaging can describe the central representation of pain or pain phenotypes and yields a basis for the development and selection of clinically relevant animal assays. This approach may increase the probability of finding meaningful new analgesics that can help satisfy the significant unmet medical needs of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.