Evidence map›Paper›PMID 28807676›Full record

ArticleNeuropharmacology2017

CRF modulates glutamate transmission in the central amygdala of naïve and ethanol-dependent rats.

Florence P Varodayan, Diego Correia, Dean Kirson, Sophia Khom, Christopher S Oleata, George Luu, Paul Schweitzer, Marisa Roberto

Abstract read
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. The Role of the Central Amygdala in Alcohol Dependence.Cold Spring Harbor perspectives in medicine · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Florence P VarodayanDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Diego CorreiaDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA; Department of Pharmacology, Universidade Federal do Paraná, Jardim das Américas, Curitiba, Paraná, CEP 81531-990, Brazil.
Dean KirsonDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Sophia KhomDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Christopher S OleataDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
George LuuDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Paul SchweitzerDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Marisa RobertoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: mroberto@scripps.edu.
Scripps Research Institute · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ERIC P ZORRILLA · 2003 to 2026
$46.3M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI RIVIER, CATHERINE L · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
Alcohol-induced neuroadapation of prefrontal cortical projectionsK99AA025408 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI VARODAYAN, FLORENCE PRABHA · 2017 to 2018
$284k
NIAAA NIH HHS K99 AA025408NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R37 AA017447NIAAA NIH HHS U01 AA013498
6 · The paper itself

Abstract

Corticotropin-releasing factor (CRF) signaling in the central nucleus of the amygdala (CeA) is hypothesized to drive the development of alcohol dependence, as it regulates ethanol intake and several anxiogenic behaviors linked to withdrawal. Excitatory glutamatergic neurotransmission contributes to alcohol reinforcement, tolerance and dependence. Therefore, in this study we used in vitro slice electrophysiology to investigate the effects of CRF and its receptor subtype (CRF

Indexed as

AlcoholismAnimalsCentral Amygdaloid NucleusCentral Nervous System DepressantsCorticotropin-Releasing HormoneCRF Receptor, Type 1Disease Models, AnimalEthanolGlutamic AcidMaleNeurotransmitter AgentsRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneSynapsesSynaptic TransmissionTissue Culture TechniquesCentral Nervous System DepressantsCorticotropin-Releasing HormoneCRF Receptor, Type 1CRF receptor type 2EthanolGlutamic AcidNeurotransmitter AgentsReceptors, Corticotropin-Releasing HormoneAlcohol/ethanolAmygdalaCRFCRF receptorElectrophysiologyGlutamate

Identifiers

PMID28807676
PMCPMC5586541
OpenAlexW2744213185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.