ReviewSeminars in perinatology2017
Preterm prelabor rupture of the membranes: A disease of the fetal membranes.
Review in Seminars in perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
166 citing papers in PubMed, 2 syntheses or guidelines pooled it, 333 citations in OpenAlex.
- Applications of Exosomes in Female Medicine: A Systematic Review of Molecular Biology, Diagnostic and Therapeutic Perspectives.International journal of molecular sciences · 2026Pooled it
- Oxidative stress biomarkers in pregnancy: a systematic review.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Maternal infection in the context of actively managed prelabor rupture of membranes at term: An observational study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Observational
- The Significance of YKL-40, a Marker Involved in Extracellular Matrix Remodeling, in Preterm Prelabor Rupture of Membranes: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2026Article
- Differential Impact of Bacterial Infection on Preterm Birth in Singleton and Twin Pregnancies and Its Association with Cervical Cerclage or Arabin Pessary: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Mitochondrial dysfunction and cellular senescence drive accelerated gestational aging in spontaneous preterm birth: a narrative review.Apoptosis : an international journal on programmed cell death · 2026Review
- Proteomic comparison of intact and fetoscopy-induced fetal membrane defect sites.Pediatric research · 2026Article
- Evaluation of the Hemoglobin, Albumin, Lymphocyte, and Platelet Score and Inflammatory Markers in Preterm Premature Rupture of Membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Amniotic Fluid Volume as a Contextual Marker of Latency and Perinatal Outcomes in Premature Prelabor Rupture of Membranes.Journal of clinical medicine · 2026Article
- RAGE-Mediated Signalling in Gynaecological Disorders: Review of Molecular Mechanisms and Therapeutic Perspectives.Expert reviews in molecular medicine · 2026Review
- Exploring the Potential of Wharton's Jelly-Derived Mesenchymal Stem Cells as a Therapeutic Approach for Preterm Premature Rupture of Membranes.International journal of stem cells · 2026Article
- Knowledge, attitudes, and practices toward premature rupture of membranes among pregnant women and their associated factors: A study at Beijing friendship hospital, Beijing, China.Preventive medicine reports · 2026Article
- Maintenance tocolysis in twin pregnancies after preterm premature rupture of membranes and neonatal outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Magnitude and associated factors of premature rupture of membranes among pregnant women admitted to a university comprehensive specialized hospital in Central Ethiopia.BMC pregnancy and childbirth · 2026Article
- MRI diagnosis of preterm prelabor rupture of membranes and uterine puncture site-amniotic cavity fistula following fetoscopic laser photocoagulation.BMC pregnancy and childbirth · 2026Article
- Exposure to traffic-related air pollution and the risk of premature rupture of membranes: a cohort analysis of the Korean CHildren's ENvironmental health Study (Ko-CHENS).Environmental science and pollution research international · 2026Article
- Establishment of a Charlson comorbidity index-based model for predicting the preterm premature rupture of the membrane.Translational pediatrics · 2026Article
- Heterogeneity in inflammatory responses to endotoxin at the fetomaternal interface.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- The Relationship Between Hypertensive Disorders of Pregnancy and PreLabor Rupture of Membranes in Ethiopia: A Systematic Review and Meta-Analysis of Observational Studies.Health science reports · 2026Review
- Tissue Specific Necroptosis in the Cervix, Uterus, and Placenta in an LPS-induced Preterm Birth Model.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
106 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Preterm prelabor rupture of the membranes (pPROM) remains a significant obstetric problem that affects 3-4% of all pregnancies and precedes 40-50% of all preterm births. pPROM arises from complex, multifaceted pathways. In this review, we summarize some old concepts and introduce some novel theories related to pPROM pathophysiology. Specifically, we introduce the concept that pPROM is a disease of the fetal membranes where inflammation-oxidative stress axis plays a major role in producing pathways that can lead to membrane weakening through a variety of processes. In addition, we report microfractures in fetal membranes that are likely sites of tissue remodeling during gestation; however, increase in number and morphometry (width and depth) of these microfractures in pPROM membranes suggests reduced remodeling capacity of membranes. Microfractures can act as channels for amniotic fluid leak, and inflammatory cell and microbial migration. Further studies on senescence activation and microfracture formation and their role in maintaining membrane homeostasis are needed to fill the knowledge gaps in our understanding of pPROM as well as provide better screening (biomarker and imaging based) tools for predicting women at high risk for pPROM and subsequent preterm birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.