Evidence map›Paper›PMID 28807150›Full record

ArticleCell calcium2017

Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin.

Le Xu, Angela C Gomez, Daniel A Pasek, Gerhard Meissner, Naohiro Yamaguchi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Le XuDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, United States.
Angela C GomezDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States; Cardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, United States.
Daniel A PasekDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, United States.
Gerhard MeissnerDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, United States.
Naohiro YamaguchiDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States; Cardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, United States. Electronic address: yamaguch@musc.edu.
University of North Carolina at Chapel Hill · USClemson University · USMedical University of South Carolina · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
SARCOPLASMIC RETICULUM FUNCTION AND REASSEMBLYR01AR018687 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEISSNER, GERHARD W · 1986 to 2009
$3.9M
SARCOPLASMIC RETICULUM FUNCTION AND REASSEMBLYR37AR018687 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEISSNER, GERHARD W · 1990 to 2019
$3.8M
Ryanodine receptor in cardiac hypertrophy and heart failureR01HL073051 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEISSNER, GERHARD W · 2003 to 2013
$3.5M
Isoform-Specific Regulation of Skeletal Muscle Calcium Channel by CalmodulinR03AR061030 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAMAGUCHI, NAOHIRO · 2011 to 2013
$218k
NCATS NIH HHS UL1 TR001450NHLBI NIH HHS R01 HL073051NIAMS NIH HHS R01 AR018687NIAMS NIH HHS R03 AR061030NIAMS NIH HHS R37 AR018687
6 · The paper itself

Abstract

The mammalian ryanodine receptor Ca

Indexed as

Amino Acid MotifsAmino Acid SequenceCalciumCalcium SignalingCalmodulinHEK293 CellsHumansLipid BilayersMutagenesisPlasmidsProtein DomainsProtein IsoformsRecombinant Fusion ProteinsRyanodine Receptor Calcium Release ChannelSequence AlignmentCalciumCalmodulinLipid BilayersProtein IsoformsRecombinant Fusion ProteinsRyanodine Receptor Calcium Release ChannelCa(2+) release channelCalmodulinCardiac muscleExcitation-contraction couplingRyanodine receptorSkeletal muscle

Identifiers

PMID28807150
PMCPMC5657546
OpenAlexW2624431553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.