Evidence map›Paper›PMID 28806967›Full record

ArticleRespiratory research2017

MicroRNA-181c inhibits cigarette smoke-induced chronic obstructive pulmonary disease by regulating CCN1 expression.

Yong Du, Yi Ding, Xuru Chen, Zhoufang Mei, Heyuan Ding, Yi Wu, Zhijun Jie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Exploring the Roles of Wnt Signaling Pathway and Non-Coding RNAs in COPD.International journal of chronic obstructive pulmonary disease · 2026
    Review
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  7. Article
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  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Long noncoding RNAActa biochimica et biophysica Sinica · 2022
    Article
  15. Hsa-Mir-320c, Hsa-Mir-200c-3p, and Hsa-Mir-449c-5p as Potential Specific miRNA Biomarkers of COPD: A Pilot Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Article
  16. Article
  17. Article
  18. Current views in chronic obstructive pulmonary disease pathogenesis and management.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yong DuDepartment of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China.
Yi DingDepartment of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China.
Xuru ChenDepartment of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China.
Zhoufang MeiDepartment of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China.
Heyuan DingDepartment of Endocrinology, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China.
Yi WuDepartment of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China.
Zhijun JieDepartment of Respiratory Medicine, The Fifth People's Hospital of Shanghai, Fudan University, No.801 Heqing Road, MinhangDistrict, Shanghai, 200240, China. jiezjlxh@163.com.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is an obstinate pulmonary disease, causing irreversible alveoli collapse and increasing the risk for cardiovascular disease. Accumulating evidence has shown that the dysregulation of miRNAs is crucially involved in the pathogenesis and development of COPD. However, the effects and role of microRNA-181c (miR-181c) have not been investigated in a murine model of COPD.

methodsmiR-181c expression was detected in human lung tissue samples of 34 patients, an in vivo murine model of CS exposure, and primary human bronchial epithelial cells (HBECs) by qRT-PCR. Degeneration of lung tissue, necrosis, infiltration and neutrophil cells were assessed with H&E and flow cytometry. Interleukin (IL)-6 and IL-8 levels were determined by an enzyme-linked immunosorbent assay and qRT-PCR. Luciferase reporter assay and correlation analyses were used to confirm and measure the levels between miR-181c and its target CCN1.

resultsWe showed that miR-181c was significantly down-regulated in lung tissues from patients with COPD compared to individuals who had never smoked (p < 0.01). We also observed a down-regulation of miR-181c in HBECs and a mouse model after cigarette smoke (CS) exposure. Functional assays demonstrated that miR-181c over-expression decreased the inflammatory response, neutrophil infiltration, reactive oxygen species (ROS) generation, and inflammatory cytokines induced by CS, while its down-regulation produced the opposite effects. Subsequent investigation found that CCN1 was a direct target of miR-181c. CCN1 expression was increased in lung tissues of COPD patients, and was negatively correlated with miR-181c expression in human COPD samples (p < 0.01).

conclusionsTaken together, our data suggest the critical roles of miR-181c and its target CCN1 in COPD development, and provide potential therapeutic targets for COPD treatment.

Indexed as

Administration, InhalationAgedAged, 80 and overAnimalsCysteine-Rich Protein 61FemaleGene ExpressionHumansLungMaleMiceMice, Inbred C57BLMicroRNAsMiddle AgedPulmonary Disease, Chronic ObstructiveRandom AllocationCCN1 protein, humanCysteine-Rich Protein 61MicroRNAsMIrn181 microRNA, humanTobacco Smoke PollutionCCN1COPDInflammatory cytokinesLung injurymiR-181c

Identifiers

PMID28806967
PMCPMC5557525
OpenAlexW2745829652

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.