ArticleBMC evolutionary biology2017
The evolutionary and coevolutionary consequences of defensive microbes for host-parasite interactions.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 55 citations in OpenAlex.
- Cross-kingdom signaling manipulation by insect-associated microbial symbionts: Linking molecular mechanisms to pest management strategies.Pest management science · 2026Review
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Host Transcriptomics Reveal Reduction in Defence-Reproduction Trade-Offs During Coinfection.Molecular ecology · 2025Article
- Immune-mediated indirect interaction between gut microbiota and bacterial pathogens.BMC biology · 2025Article
- Characterizing the evolution of defense in a tripartite marine symbiosis using adaptive dynamics.Evolution letters · 2025Article
- Microbial protection favors parasite tolerance and alters host-parasite coevolutionary dynamics.Current biology : CB · 2022Article
- Associations between Afrotropical bats, eukaryotic parasites, and microbial symbionts.Molecular ecology · 2022Article
- Coevolutionary theory of hosts and parasites.Journal of evolutionary biology · 2022Review
- The soil microbiome increases plant survival and modifies interactions with root endosymbionts in the field.Ecology and evolution · 2022Article
- Evolution and maintenance of microbe-mediated protection under occasional pathogen infection.Ecology and evolution · 2020Article
- Defensive Symbioses in Social Insects Can Inform Human Health and Agriculture.Frontiers in microbiology · 2020Article
- Protective microbiomes can limit the evolution of host pathogen defense.Evolution letters · 2019Article
- Parasite microbiome project: Grand challenges.PLoS pathogens · 2019Article
- Disruption of skin microbiota contributes to salamander disease.Proceedings. Biological sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnimal and plant species can harbour microbes that provide them with protection against enemies. These beneficial microbes can be a significant component of host defence that complement or replaces a repertoire of immunity, but they can also be costly. Given their impact on host and parasite fitness, defensive microbes have the potential to influence host-parasite interactions on an evolutionary timescale.
resultsUsing a phenotypic framework, we explore the evolutionary and coevolutionary dynamics of a host-parasite interaction in the presence of defensive microbes. We show that costs of host-defensive microbe systems are critical in determining whether a defensive microbe based system or an immune system provides better host protection investment. Partitioning the coevolutionary dynamics yields testable predictions. The density of defensive microbes influences the strength of selection resulting from host - defensive microbe - parasite coevolutionary interactions. We find that they lessen the negative effects of infection on hosts and reduce infectivity by directly competing with parasites.
conclusionsDefensive microbes might thus play a central role in host-parasite interactions, by outright replacing host-based defences, engaging in within-host competition with parasites, and ultimately driving tripartite coevolutionary dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.