ArticleBMC genomics2017
Genomic data illuminates demography, genetic structure and selection of a popular dog breed.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Beyond Appearances: The Hidden Coat Diversity of the Sicilian Mastiff Revealed by Integrated Phenotypic and Genetic Analyses.Veterinary sciences · 2026Article
- Genomic characterization of an Apennine heeling dog population: insights into diversity and conservation.Veterinary and animal science · 2026Article
- Circulating pTau181 and Genomic Background in Dogs: A Pilot Study on Neurobiological Aging.Veterinary medicine international · 2026Article
- Genetic diversity and population structure of the Taigan dog breed.FEBS open bio · 2025Article
- randPedPCA: rapid approximation of principal components from large pedigrees.Genetics, selection, evolution : GSE · 2025Article
- Genetic diversity in German Pomeranian Coarsewool sheep and the possibility of breeding for maedi-visna resistance.Archives animal breeding · 2025Article
- Genetic diversity and origin of Kazakh Tobet Dogs.Scientific reports · 2024Article
- Population Subdivision and Migration Assessment of Mangalica Pig Breeds Based on Pedigree Analysis.Animals : an open access journal from MDPI · 2024Article
- Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis.Communications biology · 2022Article
- Biologically Enhanced Genome-Wide Association Study Provides Further Evidence for Candidate Loci and Discovers Novel Loci That Influence Risk of Anterior Cruciate Ligament Rupture in a Dog Model.Frontiers in genetics · 2021Article
- Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits.Advanced genetics (Hoboken, N.J.) · 2020Article
- A Genomic Study of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels.Animals : an open access journal from MDPI · 2020Article
- Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data.Animals : an open access journal from MDPI · 2020Article
- The German Shorthair Pointer Dog Breed (Animals : an open access journal from MDPI · 2020Article
- How to study runs of homozygosity using PLINK? A guide for analyzing medium density SNP data in livestock and pet species.BMC genomics · 2020Article
- Variation in breeding practices and geographic isolation drive subpopulation differentiation, contributing to the loss of genetic diversity within dog breed lineages.Canine medicine and genetics · 2020Article
- Demographic assessment of the Dalmatian dog - effective population size, linkage disequilibrium and inbreeding coefficients.Canine medicine and genetics · 2020Article
- Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.American journal of human genetics · 2019Article
- Association between coat colour and the behaviour of Australian Labrador retrievers.Canine genetics and epidemiology · 2019Article
- The Australian dingo: untamed or feral?Frontiers in zoology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGenomic methods have proved to be important tools in the analysis of genetic diversity across the range of species and can be used to reveal processes underlying both short- and long-term evolutionary change. This study applied genomic methods to investigate population structure and inbreeding in a common UK dog breed, the Labrador Retriever.
resultsWe found substantial within-breed genetic differentiation, which was associated with the role of the dog (i.e. working, pet, show) and also with coat colour (i.e. black, yellow, brown). There was little evidence of geographical differentiation. Highly differentiated genomic regions contained genes and markers associated with skull shape, suggesting that at least some of the differentiation is related to human-imposed selection on this trait. We also found that the total length of homozygous segments (runs of homozygosity, ROHs) was highly correlated with inbreeding coefficient.
conclusionsThis study demonstrates that high-density genomic data can be used to quantify genetic diversity and to decipher demographic and selection processes. Analysis of genetically differentiated regions in the UK Labrador Retriever population suggests the possibility of human-imposed selection on craniofacial characteristics. The high correlation between estimates of inbreeding from genomic and pedigree data for this breed demonstrates that genomic approaches can be used to quantify inbreeding levels in dogs, which will be particularly useful where pedigree information is missing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.