ArticleBMC genomics2017
Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of sex-biased miRNA-mRNA pairs in gonad tissue of dark sleeper (Odontobutis potamophila).
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrated Analysis of mRNA and miRNA Associated with Reproduction in Female and Male Gonads in Abalone (International journal of molecular sciences · 2025Article
- Gonadal miRNomes and transcriptomes in infected fish reveal sexually dimorphic patterns of the immune response.Functional & integrative genomics · 2025Article
- Comparative Analysis of miRNA-mRNA Regulation in the Testes ofInternational journal of molecular sciences · 2023Article
- Comprehensive Characterization of Circular RNAs in Ovary and Testis From Nile Tilapia.Frontiers in veterinary science · 2022Article
- Effect of quercetin on muscle growth and antioxidant status of the dark sleeperFrontiers in genetics · 2022Article
- A Chromosome-Level Genome Assembly of the Dark Sleeper Odontobutis potamophila.Genome biology and evolution · 2021Article
- Integrated Analysis of mRNA- and miRNA-Seq in the Ovary of Rare MinnowFrontiers in genetics · 2021Article
- Identification and Comparison of microRNAs in the Gonad of the Yellowfin Seabream (International journal of molecular sciences · 2020Article
- Transcriptional reprogramming strategies and miRNA-mediated regulation networks of Taxus media induced into callus cells from tissues.BMC genomics · 2020Article
- Identification of miRNA-mRNA Crosstalk in Respiratory Syncytial Virus- (RSV-) Associated Pediatric Pneumonia through Integrated miRNAome and Transcriptome Analysis.Mediators of inflammation · 2020Article
- Integrated Analysis of Transcriptomic, miRNA and Proteomic Changes of a Novel Hybrid Yellow Catfish Uncovers Key Roles for miRNAs in Heterosis.Molecular & cellular proteomics : MCP · 2019Article
- Breakpoint mapping at nucleotide resolution in X-autosome balanced translocations associated with clinical phenotypes.European journal of human genetics : EJHG · 2019Article
- Identification and characteristics of muscle growth-related microRNA in the Pacific abalone, Haliotis discus hannai.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dark sleeper (Odontobutis potamophila) is an important commercial fish species which shows a sexually dimorphic growth pattern. However, the lack of sex transcriptomic data is hindering further research and genetically selective breeding of the dark sleeper. In this study, integrated analysis of mRNA and miRNA was performed on gonad tissue to elucidate the molecular mechanisms of sex determination and differentiation in the dark sleeper.
resultsA total of 143 differentially expressed miRNAs and 16,540 differentially expressed genes were identified. Of these, 8103 mRNAs and 75 miRNAs were upregulated in testes, and 8437 mRNAs and 68 miRNAs were upregulated in ovaries. Integrated analysis of miRNA and mRNA expression profiles predicted more than 50,000 miRNA-mRNA interaction sites, and among them 27,583 negative miRNA-mRNA interactions. A number of sex related genes were targeted by sex-biased miRNAs. The relationship between 15 sex-biased genes and 15 sex-biased miRNAs verified by using qRT-PCR were described. Additionally, a number of SNPs were revealed through the transcriptome data.
conclusionsThe overall results of this study facilitate our understanding of the molecular mechanism underlying sex determination and differentiation and provide valuable genomic information for selective breeding of the dark sleeper.
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