ArticleJournal of critical care2017
Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre Syndrome and encephalitis.
Article in Journal of critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Arbovirus-Associated Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis of Clinical Characteristics, Subtypes, and Vaccine Associations.Immunity, inflammation and disease · 2026Pooled it
- Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Measuring the global burden of chikungunya and Zika viruses: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype.PLoS neglected tropical diseases · 2020Pooled it
- Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review.F1000Research · 2019Pooled it
- Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
- Arboviral infections of the central nervous system: Mechanisms of invasion and long-term consequences.Journal of neurovirology · 2026Review
- Neurological complications of Zika virus and their impact on quality of life: a narrative review.Tropical medicine and health · 2026Review
- A case-control neuroimaging investigation of chronic Zika virus-infected adults.Frontiers in human neuroscience · 2026Article
- Using Data Mining to Differentiate Dengue with Warning Signs from Severe Dengue: A Predictive Model from Oaxaca, Mexico.The American journal of tropical medicine and hygiene · 2025Article
- Next-generation sequencing reveals viral aetiologies of encephalitis in Ghana: a prospective cross-sectional study.BMC infectious diseases · 2025Article
- Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024Review
- An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024Review
- Developmental Biology in Central America, the northern region of South America and the Caribbean.The International journal of developmental biology · 2021Review
- Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study.PLoS neglected tropical diseases · 2020Article
- Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers.Frontiers in immunology · 2020Article
- Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.PLoS neglected tropical diseases · 2019Article
- Late Neurological Consequences of Zika Virus Infection: Risk Factors and Pharmaceutical Approaches.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Viruses have multiple paths to central nervous system pathology.Current opinion in neurology · 2018Review
- Zika virus: a public health perspective.Current opinion in obstetrics & gynecology · 2018Review
Corrections and comments
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Authors and funding
25 authors at 19 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKAV) is classically described as causing minor symptoms in adult patients, however neurologic complications have been recognized. The recent outbreak in Central and South America has resulted in serious illness in some adult patients. We report adult patients in Latin America diagnosed with ZIKAV infection admitted to Intensive Care Units (ICUs).
methodsMulticenter, prospective case series of adult patients with laboratory diagnosis of ZIKAV in 16 ICUs in 8 countries.
resultsBetween December 1st 2015 and April 2nd 2016, 16 ICUs in 8 countries enrolled 49 critically ill patients with diagnosis of ZIKAV infection. We included 10 critically ill patients with ZIKAV infection, as diagnosed with RT-PCR, admitted to the ICU. Neurologic manifestations concordant with Guillain-Barre Syndrome (GBS) were present in all patients, although 2 evolved into an encephalitis-like picture. 2 cases died, one due to encephalitis, the other septic shock.
conclusionsDiffering from what was usually reported, ZIKAV infection can result in life-threatening neurologic illness in adults, including GBS and encephalitis. Collaborative reporting to identify severe illness from an emerging pathogen can provide valuable insights into disease epidemiology and clinical presentation, and inform public health authorities about acute care priorities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.