ArticleBiometrics2018
A matrix-based method of moments for fitting multivariate network meta-analysis models with multiple outcomes and random inconsistency effects.
Article in Biometrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effects of Caffeine Dose and Administration Method on Time-Trial Performance: A Systematic Review and Network Meta-Analysis.Nutrients · 2025Pooled it
- Comparison of the Outcomes of Endoscopic Posterolateral Interbody Fusion and Lateral Interbody Fusion in the Treatment of Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.Orthopaedic surgery · 2025Pooled it
- Evaluation of the efficacy of physical agent modalities in patients with fractures: a systematic review and network meta-analysis.Frontiers in medicine · 2025Pooled it
- Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and network meta-analysis.Human reproduction update · 2024Pooled it
- Effects of different periodontal interventions on the risk of adverse pregnancy outcomes in pregnant women: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in public health · 2024Pooled it
- Evaluation of Comparative Efficacy and Safety of Surgical Approaches for Total Hip Arthroplasty: A Systematic Review and Network Meta-analysis.JAMA network open · 2023Pooled it
- Empirical comparison of univariate and multivariate meta-analyses in Cochrane Pregnancy and Childbirth reviews with multiple binary outcomes.Research synthesis methods · 2019Pooled it
- Pooled it
- Estimation of Underlying Normal Distribution Parameters From Dichotomized Data.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Effect of bariatric surgery and pharmacological treatments on cardiovascular risk factors for adults with overweight and obesity: a systematic review and network meta-analysis.International journal of surgery (London, England) · 2026Article
- Non-invasive respiratory support in pediatric patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis of randomized controlled trials.EClinicalMedicine · 2025Article
- The Effects of Different Exercises on Insulin Resistance and Testosterone Changes in Women with Polycystic Ovarian Syndrome: A Network Meta-Analysis Study.Healthcare (Basel, Switzerland) · 2025Review
- A New Frequentist Implementation of the Daniels and Hughes Bivariate Meta-Analysis Model for Surrogate Endpoint Evaluation.Biometrical journal. Biometrische Zeitschrift · 2025Article
- Exploiting Multivariate Network Meta-Analysis: A Calibrated Bayesian Composite Likelihood Inference.Bayesian analysis · 2025Article
- Endoscopic Lumbar Interbody Fusion, Minimally Invasive Transforaminal Lumbar Interbody Fusion, and Open Transforaminal Lumbar Interbody Fusion for the Treatment of Lumbar Degenerative Diseases: A Systematic Review and Network Meta-Analysis.Global spine journal · 2024Review
- PALM: PATIENT-CENTERED TREATMENT RANKING VIA LARGE-SCALE MULTIVARIATE NETWORK META-ANALYSIS.The annals of applied statistics · 2023Article
- Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package.PloS one · 2022Article
- Classifying information-sharing methods.BMC medical research methodology · 2021Article
- Article
- Uptake of methodological advances for synthesis of continuous and time-to-event outcomes would maximize use of the evidence base.Journal of clinical epidemiology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Random-effects meta-analyses are very commonly used in medical statistics. Recent methodological developments include multivariate (multiple outcomes) and network (multiple treatments) meta-analysis. Here, we provide a new model and corresponding estimation procedure for multivariate network meta-analysis, so that multiple outcomes and treatments can be included in a single analysis. Our new multivariate model is a direct extension of a univariate model for network meta-analysis that has recently been proposed. We allow two types of unknown variance parameters in our model, which represent between-study heterogeneity and inconsistency. Inconsistency arises when different forms of direct and indirect evidence are not in agreement, even having taken between-study heterogeneity into account. However, the consistency assumption is often assumed in practice and so we also explain how to fit a reduced model which makes this assumption. Our estimation method extends several other commonly used methods for meta-analysis, including the method proposed by DerSimonian and Laird (). We investigate the use of our proposed methods in the context of both a simulation study and a real example.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.