Evidence map›Paper›PMID 28806407›Full record

SynthesisPloS one2017

Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to standard IBS diet: A meta-analysis of clinical studies.

Péter Varjú, Nelli Farkas, Péter Hegyi, András Garami, Imre Szabó, Anita Illés, Margit Solymár, Áron Vincze, Márta Balaskó, Gabriella Pár and 5 more

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03997708 (Mediterranean Diet Adjusted to Low FODMAP Diet), which is not on this map. Cited by 63 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 8 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03997708 nacompletednot on this mapstarted 2019, after this paper: background citation

Mediterranean Diet Adjusted to Low FODMAP Diet (MED-LFD) vs NICE Guidelines for Improving IBS Symptoms: a New Approach for Managing IBS

TypeinterventionalSponsorAttikon HospitalRan2019 to 2023Enrolled108ConditionsIrritable Bowel Syndrome With DiarrheaArmsMed-LFD, Nutritional Guidelines of the British National Institute for Health and Care Excellence (NICE) Managing IBS
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 8 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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  12. Nutrients · 2019
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Péter VarjúInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Nelli FarkasInstitute of Bioanalysis, University of Pécs, Pécs, Hungary.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
András GaramiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Imre SzabóDepartment of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
Anita IllésDepartment of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
Margit SolymárInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Áron VinczeDepartment of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
Márta BalaskóInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Gabriella PárDepartment of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
Judit BajorDepartment of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
Ákos SzűcsFirst Department of Surgery, Semmelweis University, Budapest, Hungary.
Orsolya HuszárFirst Department of Surgery, Semmelweis University, Budapest, Hungary.
Dániel PécsiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
József CzimmerDepartment of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.ORCID http://orcid.org/0000-0001-7831-3523
University of Pecs · HUSemmelweis University · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIrritable bowel syndrome (IBS) and functional digestive tract disorders, e.g. functional bloating, carbohydrate maldigestion and intolerances, are very common disorders frequently causing significant symptoms that challenge health care systems. A low Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) diet is one of the possible therapeutic approaches for decreasing abdominal symptoms and improving quality of life.

objectivesWe aimed to meta-analyze data on the therapeutic effect of a low-FODMAP diet on symptoms of IBS and quality of life and compare its effectiveness to a regular, standard IBS diet with high FODMAP content, using a common scoring system, the IBS Symptom Severity Score (IBS-SSS).

methodsA systematic literature search was conducted in PubMed, EMBASE and the Cochrane Library as well as in the references in a recent meta-analysis. Adult patients diagnosed with IBS according to the Rome II, Rome III, Rome IV or NICE criteria were included in the analysis. STATISTICAL

methodsMean differences with 95% confidence intervals were calculated from studies that contained means, standard deviation (SD) or mean differences and SD of differences and p-values. A random effect model was used because of the heterogeneity (Q test (χ2) and I2 indicator). A p-value of less than 0.05 was chosen to indicate a significant difference.

resultsThe literature search yielded 902 publications, but only 10 were eligible for our meta-analysis. Both regular and low-FODMAP diets proved to be effective in IBS, but post-diet IBS-SSS values were significantly lower (p = 0.002) in the low-FODMAP group. The low-FODMAP diet showed a correlation with the improvement of general symptoms (by IBS-SSS) in patients with IBS.

conclusionsThis meta-analysis provides high-grade evidence of an improved general symptom score among patients with irritable bowel syndrome who have maintained a low-FODMAP diet compared to those on a traditional IBS diet, therefore showing its superiority to regular IBS dietary therapy. These data suggest that a low-FODMAP diet with dietitian control can be a candidate for first-line therapeutic modality in IBS. Because of a lack of data, well-planned randomized controlled studies are needed to ascertain the correlation between improvement of separate key IBS symptoms and the effect of a low-FODMAP diet.

Indexed as

DietFermentationAdolescentAdultAgedAged, 80 and overClinical Trials as TopicDisaccharidesFemaleHumansIrritable Bowel SyndromeMaleMiddle AgedMonosaccharidesPolymersQuality of LifeDisaccharidesMonosaccharidesPolymerspolyol

Identifiers

PMID28806407
PMCPMC5555627
OpenAlexW2749487244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.