ReviewCurrent opinion in hematology2017
Transfusion-related immunomodulation: a reappraisal.
Review in Current opinion in hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Risk factors for pneumonia after radical gastrectomy for gastric cancer: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Transfusion thresholds for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2021Pooled it
- Retrograde autologous priming to reduce allogeneic blood transfusion requirements: a systematic review.Perfusion · 2020Pooled it
- Surgeon Perspectives on Intraoperative Cell Salvage in Liver Resection for Cancer: A National Survey of Hepatopancreatobiliary Surgeons.Annals of surgical oncology · 2026Article
- Tranexamic Acid Use Is Associated With Lower Rates of Transfusion in Patients Undergoing Revision Total Hip Arthroplasty for Periprosthetic Joint Infection.Arthroplasty today · 2026Article
- Association of red blood cell transfusions with bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.BMJ paediatrics open · 2026Article
- Development and Validation of a Machine Learning Model for Predicting Serum Creatinine-Defined Acute Kidney Injury in Older Adults After Cardiac Surgery.Clinical interventions in aging · 2026Article
- Partly intraoperative cell salvage in pediatric craniocerebral trauma: effects on coagulation function, allogeneic blood requirements, and clinical outcomes - a propensity score-matched retrospective cohort study.Frontiers in pediatrics · 2026Article
- Environmental exposures in the neonatal intensive care unit impacting neurodevelopmental outcomes for neonates.Pediatric research · 2025Review
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- When Blood Remembers Its Sex: Toward Truly Personalized Transfusion Medicine.Journal of personalized medicine · 2025Review
- Criteria used to define appropriate red blood cell transfusion in the perioperative setting: a scoping review.BMC surgery · 2025Article
- From metabolomics to transfusion-associated immunomodulation.Current opinion in immunology · 2025Review
- Deciphering the Complex Intertwining Between Cytopenia and Transfusion Needs After CAR-T-Cell Therapy for B-Cell Malignancies.Life (Basel, Switzerland) · 2025Article
- Patient Blood Management in Pediatric Patients: Current Strategies and Future PerspectivesTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Review
- Trends, risk factors, and complications of blood transfusion in primary total knee arthroplasty in China: a nationwide retrospective study.Archives of orthopaedic and trauma surgery · 2025Article
- Interactions with and activation of immune cells by CD41aFrontiers in immunology · 2025Article
- Enhancing bleeding control in total knee arthroplasty for osteoarthritis and rheumatic diseases: strategies and insights.Reumatologia · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis review summarizes current and prior observations regarding transfusion-related immunomodulation (TRIM) and puts these ideas into a modern immunological context, incorporating concepts from innate, adaptive, and nutritional immunity. We propose that TRIM research focus on determining whether there are specific, well-defined immunosuppressive effects from transfusing 'pure' red blood cells (RBCs) themselves, along with the by-products produced by the stored RBCs as a result of the 'storage lesion.' Macrophages are a key cell type involved in physiological and pathological RBC clearance and iron recycling. The plasticity and diversity of macrophages makes these cells potential mediators of immune suppression that could constitute TRIM. RECENT
findingsRecent reports identified the capacity of macrophages and monocytes to exhibit 'memory.' Exposure to various stimuli, such as engulfment of apoptotic cells and interactions with ß-glucan and lipopolysaccharide, were found to induce epigenetic, metabolic, and functional changes in certain myeloid cells, particularly macrophages and monocytes. SUMMARY: Macrophages may mediate the immunosuppressive aspects of TRIM that arise as a result of transfused RBCs and their storage lesion induced by-products.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.