ArticleNanoscale2017
Frequency-selective electrokinetic enrichment of biomolecules in physiological media based on electrical double-layer polarization.
Article in Nanoscale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Nanoscale AC Electroosmotic Flow and the Frequency-Size Scaling Observed beyond the Charge Relaxation Regime.Nano letters · 2025Article
- Experimentally profiling dielectric properties of Escherichia coli and Staphylococcus aureus by movement velocity and force.Scientific reports · 2025Article
- Protein Manipulation via Dielectrophoresis: Theoretical Principles and Emerging Microfluidic Platforms.Micromachines · 2025Review
- Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?Biosensors · 2022Review
- Single-cell microfluidic impedance cytometry: from raw signals to cell phenotypes using data analytics.Lab on a chip · 2021Article
- Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications.Sensors (Basel, Switzerland) · 2020Review
- Self-aligned microfluidic contactless dielectrophoresis device fabricated by single-layer imprinting on cyclic olefin copolymer.Analytical and bioanalytical chemistry · 2020Article
- A neural network approach for real-time particle/cell characterization in microfluidic impedance cytometry.Analytical and bioanalytical chemistry · 2020Article
- Dielectrophoresis of proteins: experimental data and evolving theory.Analytical and bioanalytical chemistry · 2020Article
- Protein Dielectrophoresis: I. Status of Experiments and an Empirical Theory.Micromachines · 2020Article
- Electrokinetic characterization of synthetic protein nanoparticles.Beilstein journal of nanotechnology · 2020Article
- Crystallization of high aspect ratio HKUST-1 thin films in nanoconfined channels for selective small molecule uptake.Nanoscale advances · 2019Article
- Low frequency cyclical potentials for fine tuning insulator-based dielectrophoretic separations.Biomicrofluidics · 2019Article
- Three-Dimensional Reservoir-Based Dielectrophoresis (rDEP) for Enhanced Particle Enrichment.Micromachines · 2018Article
- Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimer's Biomarker.Sensors (Basel, Switzerland) · 2018Article
- Electrochemical Detection of Plasma Immunoglobulin as a Biomarker for Alzheimer's Disease.Sensors (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Proteomic biomarkers of interest to the early diagnosis of diseases and infections are present at trace levels versus interfering species. Hence, their selective enrichment is needed within bio-assays for speeding binding kinetics with receptors and for reducing signal interferences. While DC fields can separate biomolecules based on their electrokinetic mobilities, they are unable to selectively enrich biomarkers versus interfering species, which may possess like-charges. We present the utilization of AC electrokinetics to enable frequency-selective enrichment of nanocolloidal biomolecules, based on the characteristic time constant for polarization of their electrical double-layer, since surface conduction in their ion cloud depends on colloidal size, shape and surface charge. In this manner, using DC-offset AC fields, differences in frequency dispersion for negative dielectrophoresis are balanced against electrophoresis in a nanoslit channel to enable the selective enrichment of prostate specific antigen (PSA) versus anti-mouse immunoglobulin antibodies that cause signal interferences to immunoassays. Through coupling enrichment to capture by receptors on graphene-modified surfaces, we demonstrate the elimination of false positives caused by anti-mouse immunoglobulin antibodies to the PSA immunoassay.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.