Evidence map›Paper›PMID 28805812›Full record

ArticleNature immunology2017

T-bet-dependent NKp46

Brandon Kwong, Rejane Rua, Yuanyuan Gao, John Flickinger, Yan Wang, Michael J Kruhlak, Jinfang Zhu, Eric Vivier, Dorian B McGavern, Vanja Lazarevic

Erratum issuedAbstract read
In one paragraph

Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Innate Lymphoid Cells.Advances in experimental medicine and biology · 2025
    Review
  6. Review
  7. Review
  8. CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis.International journal of molecular sciences · 2024
    Review
  9. Innate lymphoid cells in neuroinflammation.Frontiers in cellular neuroscience · 2024
    Review
  10. Article
  11. Natural killer cells in the central nervous system.Cell communication and signaling : CCS · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. The immunology of multiple sclerosis.Nature reviews. Immunology · 2022
    Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Brandon KwongExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0001-7184-9552
Rejane RuaViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Yuanyuan GaoExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
John FlickingerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Yan WangExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Michael J KruhlakExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jinfang ZhuLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Eric VivierAix Marseille Université, CNRS, INSERM, CIML, Marseille, France.ORCID http://orcid.org/0000-0001-7022-8287
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Vanja LazarevicExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0002-5783-7130

Funding

Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6M
Transcriptional Regulation of Immune Cell Development, Activation and FunctionsZIAAI001169 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHU, JINFANG · 2012 to 2025
$21.8M
Role of T-bet in the pathogenesis of experimental autoimmune encephalomyelitisZIABC011431 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2012 to 2025
$9.7M
EIB Microscopy Core FacilityZICBC010915 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WISNIEWSKI, JAN · 2009 to 2025
$6.1M
Regulation of T-bet expression in TH17 cells by microRNAsZIABC011432 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2012 to 2016
$2.0M
Intramural NIH HHS ZIA BC011431Intramural NIH HHS ZIA BC011432
6 · The paper itself

Abstract

The transcription factor T-bet has been associated with increased susceptibility to systemic and organ-specific autoimmunity, but the mechanism by which T-bet expression promotes neuroinflammation remains unknown. In this study, we demonstrate a cardinal role of T-bet-dependent NKp46

Indexed as

Immunity, InnateAnimalsBiomarkersCell MovementDendritic CellsDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGene ExpressionImmunophenotypingLymphocyte SubsetsMiceMice, KnockoutMyelin SheathNatural Cytotoxicity Triggering Receptor 1T-bet Transcription FactorT-Box Domain ProteinsBiomarkersNatural Cytotoxicity Triggering Receptor 1T-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID28805812
PMCPMC5605431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.