ReviewBiomolecules2017
Alcohol and Cancer: Mechanisms and Therapies.
Review in Biomolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05261620 (W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study.Nutrients · 2021Pooled it
- Association ofBioscience reports · 2019Pooled it
- Research on the Highly Efficient and Low-Dose Improvement of Alcohol-Induced Liver Injury by High-Selenium-Content Modified Lycium barbarum Polysaccharides.Biological trace element research · 2026Article
- Alcohol amount, drinking patterns, and gastric cancer risk: a nationwide study using targeted maximum likelihood estimation.European journal of epidemiology · 2026Article
- The effect of health behaviour interventions on alcohol consumption among people living with cancer: a systematic review.Journal of cancer survivorship : research and practice · 2026Review
- Health Implications of Colorism: A Narrative Review of the Literature.Journal of racial and ethnic health disparities · 2026Review
- Breast cancer pathogenesis, diagnosis and treatment: a comprehensive review.Frontiers in oncology · 2026Review
- Smoking, alcohol, and colon cancer survival are modified by immune biomarkers: a population-representative study.Carcinogenesis · 2025Article
- Review
- Network toxicology reveals collaborative mechanism of 4NQO and ethanol in esophageal squamous cell carcinogenesis.Biochemistry and biophysics reports · 2025Article
- Smoking and alcohol specific alterations in miRNA expression in head and neck squamous cell carcinoma.Discover oncology · 2025Article
- Awareness of the alcohol-breast cancer link among breast cancer survivors in the United States: a national cross-sectional survey.BMC women's health · 2025Article
- Change in alcohol consumption during the Covid-19 pandemic and associations with mental health and financial hardship: results from a survey of Wisconsin patients with cancer.Journal of cancer survivorship : research and practice · 2025Article
- Article
- SITC strategic vision: prevention, premalignant immunity, host and environmental factors.Journal for immunotherapy of cancer · 2025Review
- The exposome as a target for primary prevention and a tool for early detection of pancreatic cancer.Best practice & research. Clinical gastroenterology · 2025Review
- Revealing the potent probiotic properties and alcohol degradation capabilities ofFrontiers in microbiology · 2025Article
- Subtype-specific NK cell-TAM interactions drive a novel prognostic signature in HNSCC.Frontiers in immunology · 2025Article
- Alcohol Consumption and Breast and Ovarian Cancer Development: Molecular Pathways and Mechanisms.Current issues in molecular biology · 2024Review
- Genome analysis of a newly isolated Bacillus velezensis-YW01 for biodegrading acetaldehyde.Biodegradation · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several scientific and clinical studies have shown an association between chronic alcohol consumption and the occurrence of cancer in humans. The mechanism for alcohol-induced carcinogenesis has not been fully understood, although plausible events include genotoxic effects of acetaldehyde, cytochrome P450 2E1 (CYP2E1)-mediated generation of reactive oxygen species, aberrant metabolism of folate and retinoids, increased estrogen, and genetic polymorphisms. Here, we summarize the impact of alcohol drinking on the risk of cancer development and potential underlying molecular mechanisms. The interactions between alcohol abuse, anti-tumor immune response, tumor growth, and metastasis are complex. However, multiple studies have linked the immunosuppressive effects of alcohol with tumor progression and metastasis. The influence of alcohol on the host immune system and the development of possible effective immunotherapy for cancer in alcoholics are also discussed here. The conclusive biological effects of alcohol on tumor progression and malignancy have not been investigated extensively using an animal model that mimics the human disease. This review provides insights into cancer pathogenesis in alcoholics, alcohol and immune interactions in different cancers, and scope and future of targeted immunotherapeutic modalities in patients with alcohol abuse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.