Evidence map›Paper›PMID 28805726›Full record

ArticleToxins2017

Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo.

Kai Wang, Dongju Lin, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kai WangSchool of Pharmacy, Shenyang Pharmaceutical University, P.O. Box 21, 103 Wenhua Road, Shenyang 110016, Liaoning, China. kaiwang_2009@163.com.
Dongju LinSchool of Pharmacy, Shenyang Pharmaceutical University, P.O. Box 21, 103 Wenhua Road, Shenyang 110016, Liaoning, China. lindo.ngju@163.com.
Xiucai GuoSchool of Pharmacy, Shenyang Pharmaceutical University, P.O. Box 21, 103 Wenhua Road, Shenyang 110016, Liaoning, China. xiucai1224@163.com.
Wenlin HuangDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA. wenlin2@uw.edu.
Ying PengSchool of Pharmacy, Shenyang Pharmaceutical University, P.O. Box 21, 103 Wenhua Road, Shenyang 110016, Liaoning, China. yingpeng1999@163.com.
Jiang ZhengState Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang 550004, Guizhou, China. zhengneu@yahoo.com.
Shenyang Pharmaceutical University · CNGuiyang Medical University · CNUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diosbulbin B (DIOB), a hepatotoxic furan-containing compound, is a primary ingredient in

Indexed as

Activation, MetabolicAnimalsChemical and Drug Induced Liver InjuryCysteineDose-Response Relationship, DrugGlutathioneHeterocyclic Compounds, 4 or More RingsKetoconazoleLiverLysineMaleMiceMicrosomes, LiverProteinsCysteinediosbulbin BGlutathioneHeterocyclic Compounds, 4 or More RingsKetoconazoleLysineProteinsbromine-based analytical techniquediosbulbin Bhepatotoxicitymetabolic activationprotein covalent binding

Identifiers

PMID28805726
PMCPMC5577583
OpenAlexW2748670330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.