ReviewInternational journal of molecular sciences2017
Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of low-level light therapy in patients with dry eye: a prospective, randomized, observer-masked trial.Scientific reports · 2022Trial
- Molecular landscape connecting complications of dry eye disease: mechanisms, therapeutic targets, biomarkers, and future innovations.International ophthalmology · 2026Review
- Corticosteroid-sparing topical treatment with cyclosporin for juvenile keratoconjunctivitis.Scientific reports · 2025Article
- Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease.Investigative ophthalmology & visual science · 2024Article
- Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction.Scientific reports · 2023Article
- Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice.Biology · 2023Article
- Tribology of Pore-Textured Hard Surfaces under Physiological Conditions: Effects of Texture Scales.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Microvascular anastomosis of the human lacrimal gland: a concept study towards transplantation of the human lacrimal gland.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Viral Infection and Antiviral Treatments in Ocular Pathologies.Microorganisms · 2022Review
- Effect of multivitamin drug on intractable dry eye symptoms.Frontiers in medicine · 2022Article
- Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?International journal of molecular sciences · 2021Article
- Comprehensive Review and Update of Burning Eye Syndrome.Journal of patient-centered research and reviews · 2021Review
- Tear Metabolomics in Dry Eye Disease: A Review.International journal of molecular sciences · 2019Review
- Association Between Dry Eye Disease and Migraine Headaches in a Large Population-Based Study.JAMA ophthalmology · 2019Article
- Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Safety and efficacy of amniotic cytokine extract in the treatment of dry eye disease.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein.Progress in retinal and eye research · 2018Review
- Dry Eye Disease in Routine Rheumatology Practice.Mediterranean journal of rheumatology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin, the main risk factors are female gender and advanced age. Likewise, morphological changes in several glands and in the chemical composition of their secretions, such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors that maintain a steady ocular surface. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic inflammation that involves the ocular surface. DE syndrome is one of the most commonly encountered diseases in clinical practice, and many other causes related to daily life and the increase in average life expectancy will contribute to its onset. This review will consider the disorders of the ocular surface that give rise to such a widespread pathology. At the end, the most recent therapeutic options for the management of DE will be briefly discussed according to the specific underlying pathology.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.