Evidence map›Paper›PMID 28805667›Full record

Trial reportNutrients2017

The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial.

Wolfgang Marx, Alexandra L McCarthy, Karin Ried, Dan McKavanagh, Luis Vitetta, Avni Sali, Anna Lohning, Elisabeth Isenring

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  7. Effect ofIntegrative cancer therapies
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  15. Natural phytochemicals prevent side effects inFrontiers in pharmacology · 2022
    Review
  16. Complementary Medicine in the Treatment of Cancer Patients.Deutsches Arzteblatt international · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Wolfgang MarxFaculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD 4226, Australia. w.marx@latrobe.edu.au.
Alexandra L McCarthyDivision of Cancer Services, Princess Alexandra Hospital, and Institute of Health and Biomedical Innovation, Brisbane, QLD 4102, Australia. alexandra.mccarthy@auckland.ac.nz.
Karin RiedNational Institute of Integrative Medicine, Melbourne, VIC 3122, Australia. karinried@niim.com.au.
Dan McKavanaghSchool of Nursing, University of Auckland, Auckland 1010, New Zealand. Daniel.Mckavanagh@health.qld.gov.au.
Luis VitettaSydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. luis.vitetta@sydney.edu.au.
Avni SaliNational Institute of Integrative Medicine, Melbourne, VIC 3122, Australia. asali@niim.com.au.
Anna LohningFaculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD 4226, Australia. alohning@bond.edu.au.
Elisabeth IsenringFaculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD 4226, Australia. lisenrin@bond.edu.au.
Bond University · AUNational Institute of Integrative Medicine · AUUniversity of Auckland · NZThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic factors. Over three consecutive chemotherapy cycles, nausea was more prevalent than vomiting (47% vs. 12%). In chemotherapy Cycle 1, intervention participants reported significantly better QoL related to CIN (

Indexed as

AdultAgedAntineoplastic AgentsDouble-Blind MethodHumansMiddle AgedNauseaPlant ExtractsQuality of LifeZingiber officinaleAntineoplastic AgentsPlant ExtractscancerCINVdietary supplementsemesisgingernausea

Identifiers

PMID28805667
PMCPMC5579660
OpenAlexW2742522504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.