Evidence map›Paper›PMID 28805342›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Deletion of the activating NK cell receptor NKG2D accelerates rejection of cardiac allografts.

Cornelia Fabritius, Paul Viktor Ritschl, Thomas Resch, Mario Roth, Susanne Ebner, Julia Günther, Vanessa Mellitzer, Anh-Vu Nguyen, Johann Pratschke, Martina Sauter and 2 more

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cornelia FabritiusDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Paul Viktor RitschlDepartment of Surgery, Charité-Universitätsmedizin, Berlin, Germany.
Thomas ReschDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Mario RothDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Susanne EbnerDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Julia GüntherDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Vanessa MellitzerDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Anh-Vu NguyenDepartment of Visceral, Abdominal and Transplantation Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Johann PratschkeDepartment of Surgery, Charité-Universitätsmedizin, Berlin, Germany.
Martina SauterDepartment of Molecular Pathology, Tübingen University Hospital, Tübingen, Germany.
Karin KlingelDepartment of Molecular Pathology, Tübingen University Hospital, Tübingen, Germany.
Katja KotschDepartment of Surgery, Charité-Universitätsmedizin, Berlin, Germany.

Funding

Austrian Science Fund FWF W 1253
6 · The paper itself

Abstract

It has already been shown that neutralization of the activating NK cell receptor NKG2D in combination with co-stimulation blockade prolongs graft survival of vascularized transplants. In order to clarify the underlying cellular mechanisms, we transplanted complete MHC-disparate BALB/c-derived cardiac grafts into C57BL/6 wildtypes or mice deficient for NKG2D (Klrk1

Indexed as

AnimalsCD4-Positive T-LymphocytesGraft RejectionGraft SurvivalHeart TransplantationInterferon-gammaMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutNK Cell Lectin-Like Receptor Subfamily KPostoperative ComplicationsSurvival RateTransplantation, HomologousInterferon-gammaKlrk1 protein, mouseNK Cell Lectin-Like Receptor Subfamily Kanimal models: murinebasic (laboratory) research/scienceheart transplantation/cardiologyimmunobiologyinnate immunitynatural killer (NK) cells/NK receptorsrejection

Identifiers

PMID28805342
PMCPMC5694344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.