Evidence map›Paper›PMID 28805303›Full record

ArticleBJU international2018

Controlled release of insulin-like growth factor 1 enhances urethral sphincter function and histological structure in the treatment of female stress urinary incontinence in a rat model.

Hao Yan, Liren Zhong, Yaodong Jiang, Jian Yang, Junhong Deng, Shicheng Wei, Emmanuel Opara, Anthony Atala, Xiangming Mao, Margot S Damaser and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJU international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  10. Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Hao YanBiomedical Engineering Department of the Lerner Research Institute, Cleveland, OH, USA.
Liren ZhongInstitute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.
Yaodong JiangInstitute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.
Jian YangInstitute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.
Junhong DengDepartment of Andrology, The First People's Hospital of Guangzhou, Guangzhou, Guangdong, China.
Shicheng WeiLaboratory of Biomaterials and Regenerative Medicine, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Emmanuel OparaDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Anthony AtalaInstitute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.
Xiangming MaoDepartment of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Margot S DamaserBiomedical Engineering Department of the Lerner Research Institute, Cleveland, OH, USA.
Yuanyuan ZhangInstitute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.ORCID 0000-0002-5708-9718
Nanfang Hospital · CNWake Forest University · USCapital Medical University · CNCleveland Clinic · USGuangzhou First People's Hospital · CNPeking University · CNZhujiang Hospital · CN

Funding

Stem Cell Therapy Combined with Growth Factors for Stress Urinary IncontinenceR56DK100669 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2014 to 2014
$116k
NIDDK NIH HHS R56 DK100669
6 · The paper itself

Abstract

objectivesTo determine the effects of controlled release of insulin-like growth factor 1 (IGF-1) from alginate-poly-L-ornithine-gelatine (A-PLO-G) microbeads on external urethral sphincter (EUS) tissue regeneration in a rat model of stress urinary incontinence (SUI), as SUI diminishes the quality of life of millions, particularly women who have delivered vaginally, which can injure the urethral sphincter. Despite several well-established treatments for SUI, growth factor therapy might provide an alternative to promote urethral sphincter repair. MATERIALS AND

methodsIn all, 44 female Sprague-Dawley rats were randomised into four groups: vaginal distension (VD) followed by periurethral injection of IGF-1-A-PLO-G microbeads (VD + IGF-1 microbeads; 1 × 10

resultsUrethral function (leak-point pressure, LPP) was significantly lesser 1 week after VD + saline [mean (sem) 23.9 (1.3) cmH

conclusionPeriurethral administration of IGF-1-A-PLO-G microbeads facilitates recovery from SUI by promoting skeletal myogenesis and revascularisation. This therapy is promising, but detailed and longer term studies in animal models and humans are needed.

Indexed as

AnimalsDelayed-Action PreparationsDisease Models, AnimalFemaleInsulin-Like Growth Factor IMuscle DevelopmentMuscle, SkeletalNeovascularization, PhysiologicRatsRats, Sprague-DawleyUrethraUrinary Incontinence, StressDelayed-Action PreparationsInsulin-Like Growth Factor Iexternal urethral sphincterfemalemicrobeadsratvascularisation

Identifiers

PMID28805303
PMCPMC8121163
OpenAlexW2745564230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.