Evidence map›Paper›PMID 28805300›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

The kidney allocation system does not appropriately stratify risk of pediatric donor kidneys: Implications for pediatric recipients.

S M Nazarian, A W Peng, B Duggirala, M Gupta, T Bittermann, S Amaral, M H Levine

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Scoring donor lungs for graft failure risk: The Lung Donor Risk Index (LDRI).American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  6. Article
  7. Organ allocation in pediatric abdominal transplant.Seminars in pediatric surgery · 2022
    Article
  8. Review
  9. Donor considerations in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  10. Changes in offer and acceptance patterns for pediatric kidney transplant candidates under the new Kidney Allocation System.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  11. Article
  12. Article
  13. Pediatric deceased donor kidney transplant outcomes under the Kidney Allocation System.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. It is time to revise the kidney allocation system to restore the pediatric advantage.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

S M NazarianDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
A W PengDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
B DuggiralaDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
M GuptaDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
T BittermannDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
S AmaralDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
M H LevineDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Urological and Renal Disease Engaging Adolescents in Adherence Collaborative TrialR01DK110749 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI AMARAL, SANDRA · 2016 to 2020
$3.5M
HDAC2 Inhibition Mitigates Renal Ischemia Reperfusion InjuryR01DK106243 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEVINE, MATTHEW HOWARD · 2016 to 2020
$1.8M
Assessing an adherence intervention for adolescents with kidney transplantsK23DK083529 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI AMARAL, SANDRA · 2011 to 2015
$861k
Does geographic access to care impact pediatric ESRD outcomes?R03DK099486 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI AMARAL, SANDRA · 2014 to 2015
$184k
NIDDK NIH HHS K23 DK083529NIDDK NIH HHS R01 DK106243NIDDK NIH HHS R01 DK110749NIDDK NIH HHS R03 DK099486
6 · The paper itself

Abstract

Kidney Allocation System (KAS) was enacted in 2014 to improve graft utility, while facilitating transplantation of highly-sensitized patients and preserving pediatric access to high-quality kidneys. Central to this system is the Kidney Donor Profile Index (KDPI), a metric intended to predict transplant outcomes based on donor characteristics but derived using only adult donors. We posited that KAS had inadvertently altered the profile and quantity of kidneys made available to pediatric recipients. This question arose from our observation that most pediatric donors carry a KDPI over 35 and have therefore been rendered relatively inaccessible to pediatric recipients under KAS. Here we explore early trends in pediatric transplantation following KAS, including: (i) use of pediatric donors, (ii) use of Public Health System (PHS) high infectious risk donors, (iii) wait time, and (iv) living donor transplantation. We note some concerning preliminary changes following KAS implementation, including the allocation of fewer deceased donor pediatric kidneys to children and stagnation in pediatric wait times. Moreover, the poor predictive power of the KDPI for adult donors appears to be even worse when applied to pediatric donors. These early trends warrant further observation and consideration of changes in pediatric kidney allocation if they persist.

Indexed as

Kidney TransplantationTissue DonorsTransplant RecipientsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleMiddle Ageddonors and donation: deceasedhealth services and outcomes researchkidney (allograft) function/dysfunctionkidney transplantation/nephrologyliver allograft function/dysfunctionorgan allocationorgan procurement and allocationpediatricsrisk assessment/risk stratification

Identifiers

PMID28805300
PMCPMC5812849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.