Evidence map›Paper›PMID 28804966›Full record

ArticleAddiction (Abingdon, England)2018

Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families.

Vivia V McCutcheon, Arpana Agrawal, Sally I-Chun Kuo, Jinni Su, Danielle M Dick, Jacquelyn L Meyers, Howard J Edenberg, John I Nurnberger, John R Kramer, Samuel Kuperman and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 48 citations in OpenAlex.

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  17. The intergenerational transmission of harsh parenting, substance use, and emotional distress: Impact on the third-generation child.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Vivia V McCutcheonWashington University School of Medicine, Department of Psychiatry, St Louis, MO, USA.ORCID 0000-0002-2694-5438
Arpana AgrawalWashington University School of Medicine, Department of Psychiatry, St Louis, MO, USA.
Sally I-Chun KuoVirginia Commonwealth University, Departments of Psychology, African-American Studies, & Human and Molecular Genetics, Richmond, VA, USA.
Jinni SuVirginia Commonwealth University, Departments of Psychology, African-American Studies, & Human and Molecular Genetics, Richmond, VA, USA.
Danielle M DickVirginia Commonwealth University, Departments of Psychology, African-American Studies, & Human and Molecular Genetics, Richmond, VA, USA.
Jacquelyn L MeyersSUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, USA.
Howard J EdenbergIndiana University School of Medicine, Departments of Biochemistry and Molecular Biology, Psychiatry, Indianapolis, IN, USA.
John I NurnbergerIndiana University School of Medicine, Departments of Biochemistry and Molecular Biology, Psychiatry, Indianapolis, IN, USA.
John R KramerUniversity of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA.
Samuel KupermanUniversity of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA.
Marc A SchuckitUniversity of California San Diego, Department of Psychiatry, San Diego, CA, USA.
Victor M HesselbrockUniversity of Connecticut, Department of Psychiatry, Farmington, CT, USA.
Andrew BrooksRutgers University, Department of Genetics, New Brunswick, NJ, USA.
Bernice PorjeszSUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, USA.
Kathleen K BucholzWashington University School of Medicine, Department of Psychiatry, St Louis, MO, USA.
Virginia Commonwealth University · USWashington University in St. Louis · USIndiana University School of MedicineSUNY Downstate Health Sciences University · USUniversity of Iowa · USRutgers, The State University of New Jersey · USUniversity of Connecticut · USUniversity of San Diego · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI Jacquelyn Leigh Meyers · 1989 to 2026
$162.7M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Gene-Environment Interaction for Cannabis Use Disorders in Blacks and Whites in the U.S.K01DA037914 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI MEYERS, JACQUELYN LEIGH · 2015 to 2019
$573k
NIAAA NIH HHS K02 AA018755NIAAA NIH HHS U10 AA008401NIDA NIH HHS K01 DA037914
6 · The paper itself

Abstract

BACKGROUND AND

aimsParental alcohol use disorders (AUDs) and parental separation are associated with increased risk for early use of alcohol in offspring, but whether they increase risks for early use of other substances and for early sexual debut is under-studied. We focused on associations of parental AUDs and parental separation with substance initiation and sexual debut to (1) test the strength of the associations of parental AUDs and parental separation with time to initiation (age in years) of alcohol, tobacco and cannabis use and sexual debut and (2) compare the strength of association of parental AUD and parental separation with initiation.

designProspective adolescent and young adult cohort of a high-risk family study, the Collaborative Study on the Genetics of Alcoholism (COGA).

settingSix sites in the United States.

participantsA total of 3257 offspring (aged 14-33 years) first assessed in 2004 and sought for interview approximately every 2 years thereafter; 1945 (59.7%) offspring had a parent with an AUD. MEASUREMENTS: Diagnostic interview data on offspring substance use and sexual debut were based on first report of these experiences. Parental life-time AUD was based on their own self-report when parents were interviewed (1991-2005) for most parents, or on offspring and other family member reports for parents who were not interviewed. Parental separation was based on offspring reports of not living with both biological parents most of the time between ages 12 and 17 years.

findingsParental AUDs were associated with increased hazards for all outcomes, with cumulative hazards ranging from 1.19 to 2.71. Parental separation was also an independent and consistent predictor of early substance use and sexual debut, with hazards ranging from 1.19 to 2.34. The strength of association of parental separation with substance initiation was equal to that of having two AUD-affected parents, and its association with sexual debut was stronger than the association of parental AUD in one or both parents.

conclusionsParental alcohol use disorders (AUDs) and parental separation are independent and consistent predictors of increased risk for early alcohol, tobacco and cannabis use and sexual debut in offspring from families with a high risk of parental AUDs.

Indexed as

AdolescentAdultAlcoholismCigarette SmokingCohort StudiesDivorceFemaleHumansMaleMarijuana SmokingParentsProspective StudiesRisk FactorsSexual BehaviorUnderage DrinkingUnited StatesAlcohol use disorderscannabisCOGAearly substance usefamilialparent AUDsexual debuttobacco

Identifiers

PMID28804966
PMCPMC5760304
OpenAlexW2745088226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.