ArticleJournal of clinical periodontology2017
Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania.
Article in Journal of clinical periodontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Association between periodontitis and non-alcoholic fatty liver disease in community-dwelling adults: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies.BMC oral health · 2026Pooled it
- The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review.Clinical oral investigations · 2018Pooled it
- Association Between Oral Health and Metabolic Dysfunction-Associated Steatotic Liver Disease Among US Adults.Clinical and translational gastroenterology · 2026Article
- Periodontitis and Metabolic Dysfunction-Associated Steatotic Liver Disease: emphasizing the clinical interplay between hepatologists and dentists.Odontology · 2026Review
- Nonalcoholic fatty liver disease assessed by multiple tools are correlated to periodontal conditions.Scientific reports · 2026Article
- [Periodontitis and Metabolic Dysfunction-Associated Fatty Liver Disease: From Oral Dysbiosis to Hepatic Metabolic Dysregulation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Microbial exposure and host responses to infection reshape the disease trajectory of MASLD.Frontiers in cellular and infection microbiology · 2026Review
- The correlation between periodontitis and fatty liver and the improvement of NAFLD by periodontal treatment.Frontiers in oral health · 2026Review
- Oral health-related quality of life and oral function in patients with metabolic dysfunction associated steatotic liver disease.Clinical and experimental hepatology · 2025Article
- Association between periodontitis and mortality in participants with metabolic dysfunction-associated steatotic liver disease: results from NHANES.BMC oral health · 2025Article
- GDF15 Circulating Levels Are Associated with Metabolic-Associated Liver Injury and Atherosclerotic Cardiovascular Disease.International journal of molecular sciences · 2025Article
- Chronic Periodontitis and Non-Alcoholic Fatty Liver Disease: Recent Advances in Mechanisms of Association.International journal of general medicine · 2025Review
- Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD.Frontiers in endocrinology · 2025Article
- Advances in the study of the relationship betweenFrontiers in cell and developmental biology · 2025Review
- Periodontal diseases, potential mediators and development of liver fat content: a community-based large cohort.Frontiers in medicine · 2025Article
- Association between serum antibodies to oral microorganisms and nonalcoholic fatty liver disease in adults.BMC oral health · 2024Article
- Article
- The Molecular Comorbidity Network of Periodontal Disease.International journal of molecular sciences · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNon-alcoholic fatty liver disease (NAFLD) affects 20%-30% of adults with risk factors like obesity and insulin resistance putatively acting through chronic low-grade inflammation. Because periodontitis elicits low-grade inflammation, we hypothesized that it could contribute to NAFLD occurrence.
objectiveTo investigate epidemiologic associations between periodontitis and the incidence of NAFLD among 2,623 participants of the Study of Health in Pomerania.
methodsPeriodontitis at baseline was defined as the percentage of sites (0%, <30%, ≥30%) with (i) clinical attachment level (CAL) ≥3 mm; (ii) probing pocket depth (PD) ≥4 mm. Incident NAFLD was defined as a significant increase in liver echogenicity on ultrasound relative to the kidneys, with the diaphragm indistinct or the echogenic walls of the portal veins invisible.
resultsAfter a median 7.7 years of follow-up, 605 incident NAFLD cases occurred at a rate of 32.5 cases per 1,000 person-years. Relative to participants without CAL ≥3 mm, NAFLD incidence was elevated slightly in participants with <30% of sites affected and moderately in participants with ≥30% of sites affected (multivariable-adjusted incidence rate ratio = 1.28, 95% CI, 0.84, 1.95 and 1.60, 95% CI, 1.05-2.43), respectively. A similar dose-response relationship was not observed for PD.
conclusionHistory of periodontitis may be a risk factor for NAFLD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.