Evidence map›Paper›PMID 28804919›Full record

ArticlePediatric dermatology2017

Clinical Outcome and Prognosis of Young Patients with Mycosis Fungoides.

Pooja Virmani, Laura Levin, Patricia L Myskowski, Eileen Flores, Michael A Marchetti, Anna Skripnik Lucas, Melissa Pulitzer, Steven Horwitz, Tanya Trippett, Alison Moskowitz and 1 more

Open access · greenAbstract read
In one paragraph

Article in Pediatric dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Skin Cancer in People of Color: A Systematic Review.American journal of clinical dermatology · 2022
    Pooled it
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Update on T-Cell Lymphoma Epidemiology.Current hematologic malignancy reports · 2024
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Pooja VirmaniDepartment of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.ORCID http://orcid.org/0000-0002-1368-2034
Laura LevinDepartment of Dermatology, Weill Cornell Medical College, New York, New York.
Patricia L MyskowskiDepartment of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Eileen FloresDepartment of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Michael A MarchettiDepartment of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Anna Skripnik LucasDepartment of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Melissa PulitzerDermatopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Steven HorwitzLymphoma Services, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Tanya TrippettDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Alison MoskowitzLymphoma Services, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Christiane QuerfeldDepartment of Dermatology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

BACKGROUND/

objectivesMycosis fungoides (MF) in young patients is rare and may have atypical presentations. There are limited data in these patients. The objective was to determine the clinical outcome and prognosis of young patients with MF.

methodsA search of our institutional cancer registry database was conducted for patients diagnosed with MF at younger than 30 years of age.

resultsOur study included 74 patients (median age at diagnosis 25.5 yrs). Sixty-five (88%) presented with early stage disease and variants of MF (n = 44 [59%]), leading to a median delay in diagnosis of 2.5 years. Hypopigmented MF (n = 27 [36.5%]) was the most common variant, affecting predominantly African American (44.4% vs 19%; p = 0.02) and younger (20 vs 26 yrs; p < 0.001) patients. All patients with hypopigmented MF presented with early stage disease and were less likely to develop progressive disease (PD) than those with other variants (11% vs 34%; p = 0.03). Nineteen patients (26%) developed PD during a median follow-up of 3.5 years, which was associated with advanced-stage disease (89% vs 17%; p < 0.001), older age (>20 yrs) (31% vs 13%; p = 0.08), African American race (52.6% vs 20%; p = 0.009), and poikilodermatous presentation (p < 0.01). Overall survival was good (97.2% at 5 yrs, 95.9% at 10 yrs) despite the delay in diagnosis and atypical presentation.

conclusionsProgressive disease is associated with older age, African American race, the poikilodermatous variant, and advanced-stage disease. The hypopigmented variant is a common presentation in young patients and has an indolent disease course. Our study confirms an overall favorable prognosis in young patients with MF.

Indexed as

AdolescentAdultChildDatabases, FactualDisease ProgressionFemaleHumansMaleMycosis FungoidesPrognosisRegistriesRetrospective StudiesSkinSkin NeoplasmsSurvival RateYoung Adult

Identifiers

PMID28804919
PMCPMC5653252
OpenAlexW2748579134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.