ReviewClinical and translational imaging2017
Hybrid intraoperative imaging techniques in radioguided surgery: present clinical applications and future outlook.
Review in Clinical and translational imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surgical radioguidance with beta-emitting radionuclides; challenges and possibilities: A position paper by the EANM.European journal of nuclear medicine and molecular imaging · 2024Guideline
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- Health adjusted age and surgical outcomes in elderly oral cavity cancer patients: a case series from the Indian subcontinent.Oral and maxillofacial surgery · 2026Article
- Use of Dual-Modality Antibody Imaging for Assessment of Lymph Node Metastases in Head and Neck Cancer.Theranostics · 2026Article
- Setting-up a training programme for intraoperative molecular imaging and sentinel node mapping: how to teach? How to learn?European journal of nuclear medicine and molecular imaging · 2024Review
- Multimodality PET and Near-Infrared Fluorescence Intraoperative Imaging of CEA-Positive Colorectal Cancer.Molecular imaging and biology · 2023Article
- Article
- A High-Speed Hyperspectral Laparoscopic Imaging System.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Precision surgery: the role of intra-operative real-time image guidance - outcomes from a multidisciplinary European consensus conference.American journal of nuclear medicine and molecular imaging · 2022Article
- Value of Quantitative SPECT/CT Lymphoscintigraphy in Improving Sentinel Lymph Node Biopsy in Breast Cancer.The breast journal · 2022Article
- Simultaneous Acquisition of Ultrasound and Gamma Signals with a Single-Channel Readout.Sensors (Basel, Switzerland) · 2021Article
- Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Review
- Nuclear medicine and molecular imaging advances in the 21st century.The British journal of radiology · 2020Review
- Sentinel Node Identification in Melanoma: Current Clinical Impact, New Emerging SPECT Radiotracers and Technological Advancements. An Update of the Last Decade.Current radiopharmaceuticals · 2020Review
- Click Chemistry in the Design and Production of Hybrid Tracers.ACS omega · 2019Article
- Clinical use of an opto-nuclear probe for hybrid sentinel node biopsy guidance: first results.International journal of computer assisted radiology and surgery · 2019Article
- Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery.Theranostics · 2019Review
- Intraoperative biophotonic imaging systems for image-guided interventions.Nanophotonics (Berlin, Germany) · 2019Article
- Emerging Intraoperative Imaging Modalities to Improve Surgical Precision.Molecular imaging and biology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeThis review aims to summarise the hybrid modality radioguidance techniques currently in clinical use and development, and to discuss possible future avenues of research. Due to the novelty of these approaches, evidence of their clinical relevance does not yet exist. The purpose of this review is to inform nuclear medicine practitioners of current cutting edge research in radioguided surgery which may enter standard clinical practice within the next 5-10 years. Hybrid imaging is of growing importance to nuclear medicine diagnostics, but it is only with recent advances in technology that hybrid modalities are being investigated for use during radioguided surgery. These modalities aim to overcome some of the difficulties of surgical imaging while maintaining many benefits, or providing entirely new information unavailable to surgeons with traditional radioguidance.
methodsA literature review was carried out using online reference databases (Scopus, PubMed). Review articles obtained using this technique were citation mined to obtain further references.
resultsIn total, 2367 papers were returned, with 425 suitable for further assessment. 60 papers directly related to hybrid intraoperative imaging in radioguided surgery are reported on. Of these papers, 25 described the clinical use of hybrid imaging, 22 described the development of new hybrid probes and tracers, and 13 described the development of hybrid technologies for future clinical use. Hybrid gamma-NIR fluorescence was found to be the most common clinical technique, with 35 papers associated with these modalities. Other hybrid combinations include gamma-bright field imaging, gamma-ultrasound imaging, gamma-β imaging and β-OCT imaging. The combination of preoperative and intraoperative images is also discussed.
conclusionHybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as in sentinel node detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.