Evidence map›Paper›PMID 28804680›Full record

ReviewAmerican journal of blood research2017

Treatment of older patients with acute myeloid leukemia (AML): revised Canadian consensus guidelines.

Joseph M Brandwein, Nancy Zhu, Rajat Kumar, Brian Leber, Mitchell Sabloff, Irwindeep Sandhu, Jeannine Kassis, Harold J Olney, Mohamed Elemary, Andre C Schuh

Open access · greenAbstract readReview
In one paragraph

Review in American journal of blood research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Joseph M BrandweinDepartment of Medicine, University of AlbertaEdmonton, AB, Canada.
Nancy ZhuDepartment of Medicine, University of AlbertaEdmonton, AB, Canada.
Rajat KumarDepartment of Internal Medicine, University of ManitobaWinnipeg, MB, Canada.
Brian LeberDepartment of Medicine, McMaster UniversityHamilton, ON, Canada.
Mitchell SabloffDepartment of Medicine, University of OttawaOttawa, ON, Canada.
Irwindeep SandhuDepartment of Medicine, University of AlbertaEdmonton, AB, Canada.
Jeannine KassisDepartment of Medicine, Université de MontréalMontreal, QC, Canada.
Harold J OlneyDepartment of Medicine, Université de MontréalMontreal, QC, Canada.
Mohamed ElemarySaskatoon Cancer Centre, University of SaskatchewanSaskatoon, SK, Canada.
Andre C SchuhPrincess Margaret Cancer Centre, University of TorontoToronto, ON, Canada.
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of acute myeloid leukemia (AML) in older patients is undergoing rapid changes, with a number of important publications in the past five years. Because of this, a group of Canadian leukemia experts has produced an update to the Canadian Consensus Guidelines that were published in 2013, with several new agents recommended, subject to availability. Recent studies have supported the survival benefit of induction chemotherapy for patients under age 80, except those with major co-morbidities or those with adverse risk cytogenetics who are not candidates for allogeneic hematopoietic stem cell transplantation (HSCT). Midostaurin should be added to induction therapy for patients up to age 70 with a FLT3 mutation, and gemtuzumab ozogamicin for de novo AML up to age 70 with favorable or intermediate risk cytogenetics. Daunorubicin 60 mg/m

Indexed as

Acute myeloid leukemiachemotherapyco-morbiditiescytogeneticselderly patientshematopoietic stem cell transplantationhypomethylating agents

Identifiers

PMID28804680
PMCPMC5545212
OpenAlexW2976049443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.