ArticleNature biomedical engineering2017
Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.
Article in Nature biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 279 citations in OpenAlex.
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- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Two-dimensional semiconductor-based active array for high-fidelity spatiotemporal monitoring of neural activities.Nature materials · 2026Article
- Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Laser Micromachining for Bioelectronics: Past, Present, and Future.Small methods · 2026Review
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- An Active, Multimodal Neural Interface for Real-Time Monitoring of Cortical Electrical, Thermal, and Optical Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Photonic Nanomaterials for Wearable Health Solutions.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- An Implantable, Ultralow Distortion Bioelectronic Interface Integrating Light-Emitting Diodes and Graphene Field-Effect Transistors.ACS nano · 2025Article
- Monolithic three-dimensional neural probes from deterministic rolling of soft electronics.Nature electronics · 2025Article
- Materials Advances in Devices for Heart Disease Interventions.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025Article
- Fabrication of Anti-Reflective Composite Structures on Inverted Pyramids Using Inductively Coupled Plasma Etching.Micromachines · 2025Article
- Integrating Hard Silicon for High-Performance Soft Electronics via Geometry Engineering.Nano-micro letters · 2025Review
- Fully 3D-Printed Soft Capacitive Sensor of High Toughness and Large Measurement Range.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Transient electronics for sustainability: Emerging technologies and future directions.Beilstein journal of nanotechnology · 2025Article
- Materials and devices for high-density, high-throughput micro-electrocorticography arrays.Fundamental research · 2025Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 2 countries.
Funding
Abstract
Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying layer of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, and thus without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of any other flexible-electronics technology. Systematic electrophysiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. Our technology provides a realistic pathway towards the broad applicability of biocompatible, flexible electronic implants.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.