Evidence map›Paper›PMID 28804598›Full record

ArticleJournal of extracellular vesicles2017

A rigorous method to enrich for exosomes from brain tissue.

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed.

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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura J VellaThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.ORCID 0000-0002-1869-6291
Benjamin J SciclunaDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Australia.ORCID 0000-0001-6828-9910
Lesley ChengDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Emma G BawdenThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.
Colin L MastersThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.
Ching-Seng AngThe Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia.
Nicholas WillamsonThe Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia.
Catriona McLeanThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.
Kevin J BarnhamThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia.
Andrew F HillDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Australia.ORCID 0000-0001-5581-2354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles, including exosomes, are released by all cells, including those of the nervous system. Capable of delivering lipid, protein and nucleic acids to both nearby and distal cells, exosomes have been hypothesized to play a role in progression of many diseases of the nervous system. To date, most analyses on the role of these vesicles in the healthy and diseased state have relied on studying vesicles from

Indexed as

brainenrichmentExosomesextracellular vesiclesfrontal cortextissue

Identifiers

PMID28804598
PMCPMC5533148

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.