Evidence map›Paper›PMID 28804559›Full record

ArticleAmerican journal of translational research2017

MicroRNA-1907 enhances atherosclerosis-associated endothelial cell apoptosis by suppressing Bcl-2.

Jin Zhao, Shu-Lin Ou, Wei-You Wang, Chang Yan, Lu-Xiang Chi

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Elucidation of the Hdac2/Sp1/Molecular therapy. Nucleic acids · 2021
    Article
  4. Article
  5. Protective Effects of Total Saponins ofInternational journal of molecular sciences · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jin ZhaoCenter of Translational Medicine, College of Pharmacy, Third Military Medical UniversityChongqing 400038, China.
Shu-Lin OuDepartment of Cardiology, Southwest Hospital, Third Military Medical UniversityChongqing 400038, China.
Wei-You WangThird Department of Internal Medicine, Chongqing Thirteenth People's HospitalChongqing 400053, China.
Chang YanDepartment of Cardiology, Southwest Hospital, Third Military Medical UniversityChongqing 400038, China.
Lu-Xiang ChiDepartment of Cardiology, Southwest Hospital, Third Military Medical UniversityChongqing 400038, China.
Army Medical University · CNThird People 's Hospital of Chongqing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injury and endothelial cell apoptosis are hall marks of atherosclerosis (AS). However, the mechanisms underlying its pathogenesis remain ill-defined. Recent evidence of a role for microRNAs in AS-associated endothelial cell apoptosis encouraged us to address this question. Here, AS was developed in ApoE (-/-) mice supplied with a high-fat diet (HFD), compared to ApoE (-/-) mice supplied with a normal diet (ND). Mouse endothelial cells were isolated from the aortic arch using flow cytometry based on their expression of CD31. Human aortic endothelial cells (HAECs) were treated with oxidized low-density lipoprotein (ox-LDL) as an

Indexed as

ApoE (-/-)AtherosclerosisBcl-2endothelial cell apoptosishigh fat diet (HFD)miR-1907ox-LDL

Identifiers

PMID28804559
PMCPMC5527257
OpenAlexW2974110143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.