Evidence map›Paper›PMID 28804558›Full record

ArticleAmerican journal of translational research2017

NADPH oxidase 2 inhibitor diphenyleneiodonium enhances ROS-independent bacterial phagocytosis in murine macrophages via activation of the calcium-mediated p38 MAPK signaling pathway.

Yuanfeng Zhu, Shijun Fan, Ning Wang, Xiaoli Chen, Yongjun Yang, Yongling Lu, Qian Chen, Jiang Zheng, Xin Liu

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuanfeng ZhuMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Shijun FanMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Ning WangMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Xiaoli ChenMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Yongjun YangMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Yongling LuMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Qian ChenMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Jiang ZhengMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Xin LiuMedical Research Center, Southwest Hospital, Third Military Medical UniversityChongqing, China.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of NADPH oxidase 2 (NOX2) triggers reactive oxygen species (ROS) generation, both of which are essential for robust microbial clearance by phagocytes. However, it is unknown whether inhibition of NOX2 activation or ROS generation affects cellular phagocytosis. Here, we found that the classic NOX2 inhibitor diphenyleneiodonium (DPI) induced uptake of

Indexed as

DiphenyleneiodoniumE. colimacrophagesp38 MAPKphagocytosis

Identifiers

PMID28804558
PMCPMC5527256
OpenAlexW3021244969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.