ReviewFrontiers in physiology2017
Heat Acclimation-Mediated Cross-Tolerance: Origins in within-Life Epigenetics?
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Prolactin and heat stress; focus on domestic ruminants.Journal of animal science · 2025Review
- Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.International journal of biological sciences · 2025Article
- Embryonic manipulations shape life-long, heritable stress responses through complex epigenetic mechanisms: a review.Frontiers in neuroscience · 2024Review
- Defining adaptation within applied physiology - is there room for improvement?Frontiers in physiology · 2024Article
- Vascular compliance and left ventricular compliance cross talk: Implications for using long-term heat acclimation in cardiac care.Frontiers in physiology · 2023Review
- Climate change and pregnancy complications: From hormones to the immune response.Frontiers in endocrinology · 2023Review
- Epigenetic responses to heat: From adaptation to maladaptation.Experimental physiology · 2022Review
- Human total fertility rate affected by ambient temperatures in both the present and previous generations.International journal of biometeorology · 2021Article
- Embryonic Heat Conditioning Induces TET-Dependent Cross-Tolerance to Hypothalamic Inflammation Later in Life.Frontiers in genetics · 2020Article
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- TREM2 Regulates Heat Acclimation-Induced Microglial M2 Polarization Involving the PI3K-Akt Pathway Following EMF Exposure.Frontiers in cellular neuroscience · 2019Article
- Thermal Manipulation During Embryogenesis Impacts H3K4me3 and H3K27me3 Histone Marks in Chicken Hypothalamus.Frontiers in genetics · 2019Article
- Application of evidence-based recommendations for heat acclimation: Individual and team sport perspectives.Temperature (Austin, Tex.) · 2019Review
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The primary outcome of heat acclimation is increased thermotolerance, which stems from enhancement of innate cytoprotective pathways. These pathways produce "ON CALL" molecules that can combat stressors to which the body has never been exposed, via cross-tolerance mechanisms (heat acclimation-mediated cross-tolerance-HACT). The foundation of HACT lies in the sharing of generic stress signaling, combined with tissue/organ- specific protective responses. HACT becomes apparent when acclimatory homeostasis is achieved, lasts for several weeks, and has a memory. HACT differs from other forms of temporal protective mechanisms activated by exposure to lower "doses" of the stressor, which induce adaptation to higher "doses" of the same/different stressor; e.g., preconditioning, hormesis. These terms have been adopted by biochemists, toxicologists, and physiologists to describe the rapid cellular strategies ensuring homeostasis. HACT employs two major protective avenues: constitutive injury attenuation and abrupt post-insult release of help signals enhanced by acclimation. To date, the injury-attenuating features seen in all organs studied include fast-responding, enlarged cytoprotective reserves with HSPs, anti-oxidative, anti-apoptotic molecules, and HIF-1α nuclear and mitochondrial target gene products. Using cardiac ischemia and brain hypoxia models as a guide to the broader framework of phenotypic plasticity, HACT is enabled by a metabolic shift induced by HIF-1α and there are less injuries caused by Ca
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