Evidence map›Paper›PMID 28804446›Full record

ArticleFrontiers in molecular neuroscience2017

Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect.

Emily B Harrison, Katy Emanuel, Benjamin G Lamberty, Brenda M Morsey, Min Li, Matthew L Kelso, Sowmya V Yelamanchili, Howard S Fox

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
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  4. Observational
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  8. Review
  9. MicroRNAFrontiers in molecular neuroscience · 2022
    Article
  10. MiR-155: An Important Regulator of Neuroinflammation.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
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  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Emily B HarrisonDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
Katy EmanuelDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
Benjamin G LambertyDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
Brenda M MorseyDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
Min LiDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
Matthew L KelsoDepartment of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical CenterOmaha, NE, United States.
Sowmya V YelamanchiliDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
Howard S FoxDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical CenterOmaha, NE, United States.
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

CAROLINA CANCER NANOTECHNOLOGY TRAINING PROGRAM (C-CNTP)T32CA196589 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Gaorav P. Gupta, ALEXANDER V KABANOV · 2015 to 2026
$4.5M
NCI NIH HHS T32 CA196589
6 · The paper itself

Abstract

Traumatic brain injury (TBI) produces profound and lasting neuroinflammation that has both beneficial and detrimental effects. Recent evidence has implicated microRNAs (miRNAs) in the regulation of inflammation both in the periphery and the CNS. We examined the expression of inflammation associated miRNAs in the context of TBI using a mouse controlled cortical impact (CCI) model and found increased levels of miR-21, miR-223 and miR-155 in the hippocampus after CCI. The expression of miR-155 was elevated 9-fold after CCI, an increase confirmed by

Indexed as

gene expressioninflammationinjuryneurodegeneration

Identifiers

PMID28804446
PMCPMC5532436
OpenAlexW2734372389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.