Evidence map›Paper›PMID 28804222›Full record

ArticleMediators of inflammation2017

Chemical Chaperone of Endoplasmic Reticulum Stress Inhibits Epithelial-Mesenchymal Transition Induced by TGF-

Heung-Man Lee, Ju-Hyung Kang, Jae-Min Shin, Seoung-Ae Lee, Il-Ho Park

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. [Mechanisms of HNE mediated NLRP3 promoting EMT in chronic rhinosinusitis with polyps].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  2. Article
  3. Epithelial-Mesenchymal Transition in Chronic Rhinosinusitis.Journal of rhinology : official journal of the Korean Rhinologic Society · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Impact of Endoplasmic Reticulum Stress in Otorhinolaryngologic Diseases.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Heung-Man LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.
Ju-Hyung KangDepartment of Biomedical Sciences, Korea University Graduate School, Seoul, Republic of Korea.
Jae-Min ShinDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.
Seoung-Ae LeeMedical Devices Clinical Trial Center, Guro Hospital, Korea University, Seoul, Republic of Korea.
Il-Ho ParkDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0002-7011-6071
Korea University · KRKorea University Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) is a biological process that allows epithelial cells to assume a mesenchymal cell phenotype. EMT is considered as a therapeutic target for several persistent inflammatory airway diseases related to tissue remodeling. Herein, we investigated the role of endoplasmic reticulum (ER) stress and c-Src in TGF-

Indexed as

A549 CellsCell MovementEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEpithelial-Mesenchymal TransitionGenes, srcHumansNasal PolypsOrgan Culture TechniquesSignal TransductionTransforming Growth Factor beta1Endoplasmic Reticulum Chaperone BiPHSPA5 protein, humanTransforming Growth Factor beta1

Identifiers

PMID28804222
PMCPMC5540463
OpenAlexW2736411315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.