Evidence map›Paper›PMID 28804142›Full record

ArticleBiometrika2016

An adaptive two-sample test for high-dimensional means.

Gongjun Xu, Lifeng Lin, Peng Wei, Wei Pan

Abstract read
In one paragraph

Article in Biometrika, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Hybrid test for publication bias in meta-analysis.Statistical methods in medical research · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Projection Test for Mean Vector in High Dimensions.Journal of the American Statistical Association · 2024
    Article
  9. Article
  10. Finite sample t-tests for high-dimensional means.Journal of multivariate analysis · 2023
    Article
  11. Article
  12. Article
  13. Linear Hypothesis Testing in Linear Models With High-Dimensional Responses.Journal of the American Statistical Association · 2022
    Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gongjun XuSchool of Statistics, University of Minnesota, Minneapolis, Minnesota, U.S.A. 55455.
Lifeng LinDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, U.S.A. 55455.
Peng WeiDivision of Biostatistics and Human Genetics Center, University of Texas School of Public Health, Houston, Texas, U.S.A. 77030.
Wei PanDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, U.S.A. 55455.

Funding

Association analysis of rare variants with sequencing dataR01HL116720 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAN, WEI, WEI, PENG · 2013 to 2020
$3.3M
Powerful Inference and Prediction for Genetic AssociationR01HL105397 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAN, WEI, SHEN, XIAOTONG TOM · 2011 to 2018
$2.9M
Statistical Methods for Genomic DataR01GM113250 · NIGMS · UNIVERSITY OF MINNESOTA · PI PAN, WEI · 2014 to 2017
$702k
NHLBI NIH HHS R01 HL105397NHLBI NIH HHS R01 HL116720NIGMS NIH HHS R01 GM113250Wellcome Trust
6 · The paper itself

Abstract

Several two-sample tests for high-dimensional data have been proposed recently, but they are powerful only against certain limited alternative hypotheses. In practice, since the true alternative hypothesis is unknown, it is unclear how to choose a powerful test. We propose an adaptive test that maintains high power across a wide range of situations, and study its asymptotic properties. Its finite sample performance is compared with existing tests. We apply it and other tests to detect possible associations between bipolar disease and a large number of single nucleotide polymorphisms on each chromosome based on a genome-wide association study dataset. Numerical studies demonstrate the superior performance and high power of the proposed test across a wide spectrum of applications.

Indexed as

Genome-wide association studySingle nucleotide polymorphismsSum-of-powers test

Identifiers

PMID28804142
PMCPMC5549874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.