Evidence map›Paper›PMID 28803993›Full record

ArticleCancer letters2017

Nanoemulsion formulation of a novel taxoid DHA-SBT-1214 inhibits prostate cancer stem cell-induced tumor growth.

Gulzar Ahmad, Rana El Sadda, Galina Botchkina, Iwao Ojima, James Egan, Mansoor Amiji

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Cancer letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 60 citations in OpenAlex.

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  16. Current Applications of Nanoemulsions in Cancer Therapeutics.Nanomaterials (Basel, Switzerland) · 2019
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gulzar AhmadDepartment of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, 02115-5000, USA.
Rana El SaddaInstitute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, 11794-3400, USA.
Galina BotchkinaInstitute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, 11794-3400, USA; Department of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY, 11794-8691, USA.
Iwao OjimaInstitute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, 11794-3400, USA; Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794-3400, USA.
James EganTargagenix, Inc., 25 Health Sciences Drive, Stony Brook, NY, 11790-3382, USA.
Mansoor AmijiDepartment of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, 02115-5000, USA. Electronic address: m.amiji@northeastern.edu.
Stony Brook University · USNortheastern University · USTargaGenix (United States) · US

Funding

Tumor -Targeting Chemotherapeutic AgentsR01CA103314 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI OJIMA, IWAO · 2003 to 2013
$3.1M
Preclinical Studies on Polyunsaturated Fatty Acid-Taxoid Conjugate for IND FilingR44CA132396 · NCI · CHEM-MASTER INTERNATIONAL, INC · PI GUPTA, RAMESH CHANDER · 2010 to 2011
$2.7M
COMBINATORIAL-DESIGNED NANO-PLATFORMS TO OVERCOME TUMOR DRUG RESISTANCEU01CA151452 · NCI · NORTHEASTERN UNIVERSITY · PI AMIJI, MANSOOR M., DUAN, ZHENFENG · 2010 to 2014
$2.1M
Targeted Platinates/siRNA Combination Therapy for Resistant Lung CancerR21CA179652 · NCI · NORTHEASTERN UNIVERSITY · PI AMIJI, MANSOOR M., IYER, ARUN · 2014 to 2015
$372k
PROSTATE CANCER STEM CELL-TARGETED ACTIVITY OF A NEW-GENERATION TAXOIDSR21CA150085 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BOTCHKINA, GALINA I · 2010 to 2011
$371k
NCI NIH HHS HHSN261201500018CNCI NIH HHS R01 CA103314NCI NIH HHS R21 CA150085NCI NIH HHS R21 CA179652NCI NIH HHS R44 CA132396NCI NIH HHS U01 CA151452
6 · The paper itself

Abstract

The main aim of this study was to evaluate the therapeutic efficacy of an oil-in-water nanoemulsion formulation encapsulating DHA-SBT-1214, a novel omega-3 fatty acid conjugated taxoid prodrug, against prostate cancer stem cells. Nanoemulsions of DHA-SBT-1214 (NE-DHA-SBT-1214) were prepared and characterized. In vitro delivery efficiency and cytotoxicity of NE-DHA-SBT-1214 was compared with solution formulation in PPT2 cells. In vivo studies included analysis of comparative efficacy of NE-DHA-SBT-1214 with Abraxane

Indexed as

AnimalsCell SurvivalDocosahexaenoic AcidsDrug CompoundingEmulsionsHumansMaleMice, Inbred NODMice, SCIDNanoparticlesNeoplastic Stem CellsProstatic NeoplasmsTaxoidsTumor Cells, CulturedXenograft Model Antitumor AssaysDocosahexaenoic AcidsEmulsionsSB T-1214TaxoidsCancer stem cellsNanoemulsion formulationProstate cancerTaxoid

Identifiers

PMID28803993
PMCPMC5591776
OpenAlexW2744091972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.