ArticleDevelopmental biology2017
IGDB-2, an Ig/FNIII protein, binds the ion channel LGC-34 and controls sensory compartment morphogenesis in C. elegans.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- Analysis ofComputational and structural biotechnology journal · 2024Article
- C. elegans as a model to study glial development.The FEBS journal · 2022Review
- Patched-Related Is Required for Proper Development of EmbryonicFrontiers in neuroscience · 2022Article
- Meta-Analysis ofFrontiers in microbiology · 2022Article
- Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening inmicroPublication biology · 2022Article
- DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.PLoS genetics · 2021Article
- Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.PLoS genetics · 2021Article
- Review
- Morphogenesis of neurons and glia within an epithelium.Development (Cambridge, England) · 2019Article
- Cell-type-specific promoters forJournal of neurogeneticsArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Sensory organ glia surround neuronal receptive endings (NREs), forming a specialized compartment important for neuronal activity, and reminiscent of glia-ensheathed synapses in the central nervous system. We previously showed that DAF-6, a Patched-related protein, is required in glia of the C. elegans amphid sensory organ to restrict sensory compartment size. LIT-1, a Nemo-like kinase, and SNX-1, a retromer component, antagonize DAF-6 and promote compartment expansion. To further explore the machinery underlying compartment size control, we sought genes whose inactivation restores normal compartment size to daf-6 mutants. We found that mutations in igdb-2, encoding a single-pass transmembrane protein containing Ig-like and fibronectin type III domains, suppress daf-6 mutant defects. IGDB-2 acts in glia, where it localizes to glial membranes surrounding NREs, and, together with LIT-1 and SNX-1, regulates compartment morphogenesis. Immunoprecipitation followed by mass spectrometry demonstrates that IGDB-2 binds to LGC-34, a predicted ligand-gated ion channel, and lgc-34 mutations inhibit igdb-2 suppression of daf-6. Our findings reveal a novel membrane protein complex and suggest possible mechanisms for how sensory compartment size is controlled.
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