Evidence map›Paper›PMID 28803965›Full record

ArticleNeuropharmacology2017

The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB

Thomas F Gamage, Charlotte E Farquhar, Timothy W Lefever, Brian F Thomas, Thuy Nguyen, Yanan Zhang, Jenny L Wiley

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Negative allosteric modulation of CBNeuropharmacology · 2024
    Article
  2. Article
  3. Article
  4. Negative allosteric modulation of CBPharmacological research · 2022
    Article
  5. Article
  6. Review of the Endocannabinoid System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Review
  7. Sex, species and age: Effects of rodent demographics on the pharmacology of ∆Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Article
  8. In vivo evaluation of the CBPharmacology, biochemistry, and behavior · 2020
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling.Frontiers in molecular neuroscience · 2019
    Article
  15. Endocannabinoids in Body Weight Control.Pharmaceuticals (Basel, Switzerland) · 2018
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas F GamageRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA. Electronic address: tgamage@rti.org.
Charlotte E FarquharRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA.
Timothy W LefeverRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA.
Brian F ThomasRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA.
Thuy NguyenRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA.
Yanan ZhangRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA.
Jenny L WileyRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194, USA.
RTI International · US

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
THC RECEPTORSR37DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, BILLY R · 1997 to 2006
$2.8M
Allosteric Modulation of the CB1 ReceptorR01DA040693 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZHANG, YANAN · 2016 to 2020
$2.4M
NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA040460NIDA NIH HHS R01 DA040693NIDA NIH HHS R37 DA003672
6 · The paper itself

Abstract

While allosteric modulators of the cannabinoid type-1 receptor (CB

Indexed as

Allosteric RegulationAnimalsCannabinoid Receptor ModulatorsCerebellumCyclohexanolsDiscrimination, PsychologicalDose-Response Relationship, DrugDronabinolDrug InteractionsGuanosine 5'-O-(3-Thiotriphosphate)MaleMice, Inbred C57BLMice, Inbred ICRMotor ActivityPhenylurea CompoundsPiperidines1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolCannabinoid Receptor ModulatorsCNR1 protein, mouseCyclohexanolsDronabinolGuanosine 5'-O-(3-Thiotriphosphate)Phenylurea CompoundsPiperidinesPregnenolonePyrazolesPyridinesReceptor, Cannabinoid, CB1RimonabantAllosteric modulationBehavioralCannabinoidsReceptor bindingSignaling

Identifiers

PMID28803965
PMCPMC5771238
OpenAlexW2743512737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.