Evidence map›Paper›PMID 28803923›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2018

Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.

Jennifer A Ross, Gediminas Gliebus, Elisabeth J Van Bockstaele

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 60 citations in OpenAlex.

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  19. Modifiable Risk Factors for Alzheimer's Disease.Frontiers in aging neuroscience · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jennifer A RossDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA 19102, United States. Electronic address: jar485@drexel.edu.
Gediminas GliebusDepartment of Neurology, Drexel Neuroscience Institute, Philadelphia, PA 19107, United States.
Elisabeth J Van BockstaeleDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA 19102, United States.
Drexel University · US

Funding

OPIOID MODULATION OF THE COERULEO-CORTICAL PATHWAYR01DA009082 · NIDA · THOMAS JEFFERSON UNIVERSITY · PI VAN BOCKSTAELE, ELISABETH J · 2001 to 2017
$6.0M
Modulation of norepinephrine by cannabinoidsR01DA020129 · NIDA · THOMAS JEFFERSON UNIVERSITY · PI VAN BOCKSTAELE, ELISABETH J · 2005 to 2017
$3.5M
Norepinephrine: A Novel Regulator of Amyloid Beta-42 PeptidesR21AG058263 · NIA · DREXEL UNIVERSITY · PI THOMAS, STEVEN A, VAN BOCKSTAELE, ELISABETH J · 2018 to 2019
$458k
NIA NIH HHS R21 AG058263NIDA NIH HHS R01 DA009082NIDA NIH HHS R01 DA020129
6 · The paper itself

Abstract

Chronic stress is a risk factor for a number of physiological disorders including cardiovascular disease, obesity and gastrointestinal disorders, as well as psychiatric and neurodegenerative disorders. There are a number of underlying molecular and cellular mechanisms altered in the course of chronic stress, which may increase the vulnerability of individuals to develop psychiatric disorders such as depression, and neurodegenerative disorders such as Alzheimer's Disease (AD). This is evident in the influence of stress on large-scale brain networks, including the resting state Default Mode Network (DMN), the effects of stress on neuronal circuitry and architecture, and the cellular and molecular adaptations to stress, which may render individuals with stress related psychiatric disorders more vulnerable to neurodegenerative disease later in life. These alterations include decreased negative feedback inhibition of the hypothalamic pituitary axis (HPA) axis, decreased dendritic arborization and spine density in the prefrontal cortex (PFC) and hippocampus, and the release of proinflammatory cytokines, which may suppress neurogenesis and promote neuronal cell death. Each of these factors are thought to play a role in stress-related psychiatric disease as well as AD, and have been observed in clinical and post-mortem studies of individuals with depression and AD. The goal of the current review is to summarize clinical and preclinical evidence supporting a role for chronic stress as a putative link between neuropsychiatric and neurodegenerative disease. Moreover, we provide a rationale for the importance of taking a medical history of stress-related psychiatric diseases into consideration during clinical trial design, as they may play an important role in the etiology of AD in stratified patient populations.

Indexed as

Alzheimer DiseaseAnimalsBrainDepressive DisorderHumansModels, NeurologicalStress, PsychologicalAdrenergic receptorsAmyloidDepressionDopamine-β-hydroxylaseNorepinephrineStress

Identifiers

PMID28803923
PMCPMC5809232
OpenAlexW2742396863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.