ArticleCurrent biology : CB2017
Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Effect of Non- and Low-Caloric Sweeteners on Substrate Oxidation, Energy Expenditure, and Catecholamines in Humans-A Systematic Review.Nutrients · 2023Pooled it
- Trial
- Trial
- Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.Cell metabolism · 2020Trial
- Trial
- Ultraprocessed foods evoke distinct metabolic and neural responses.Nature metabolism · 2026Article
- Metabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study.Nature metabolism · 2026Article
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- Sugar reduction in complex food systems: linking metabolic mechanisms, matrix engineering, and safety evaluation.NPJ science of food · 2026Review
- Effects of Controlled Diets High in and Free of Ultraprocessed Food on the Brain of Emerging Adults.medRxiv : the preprint server for health sciences · 2026Article
- Acute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence: the mediating role of prefrontal cortical activity.Frontiers in nutrition · 2026Article
- Adaptive Identification of Food Sweetness Concentration: An Electroencephalogram Feature Classification Network Under Taste Stimulation.Foods (Basel, Switzerland) · 2025Article
- Metrics of glycemic control but not body weight influence flavor nutrient conditioning in humans.Physiology & behavior · 2025Article
- Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.Physiology & behavior · 2025Review
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Tastes and retronasal odours evoke a shared flavour-specific neural code in the human insula.Nature communications · 2025Article
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Effect of sweet and caloric drinks on cardiac reactivity to slow-paced breathing in healthy adults.Scientific reports · 2025Article
- Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery.PLoS biology · 2024Article
- Neural and metabolic factors in carbohydrate reward: Rationale, design, and methods for a flavor-nutrient learning paradigm in humans.Contemporary clinical trials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Post-ingestive signals related to nutrient metabolism are thought to be the primary drivers of reinforcement potency of energy sources. Here, in a series of neuroimaging and indirect calorimetry human studies, we examine the relative roles of caloric load and perceived sweetness in driving metabolic, perceptual, and brain responses to sugared beverages. Whereas caloric load was manipulated using the tasteless carbohydrate maltodextrin, sweetness levels were manipulated using the non-nutritive sweetener sucralose. By formulating beverages that contain different amounts of maltodextrin+sucralose, we demonstrate a non-linear association between caloric load, metabolic response, and reinforcement potency, which is driven in part by the extent to which sweetness is proportional to caloric load. In particular, we show that (1) lower-calorie beverages can produce greater metabolic response and condition greater brain response and liking than higher-calorie beverages and (2) when sweetness is proportional to caloric load, greater metabolic responses are observed. These results demonstrate a non-linear association between caloric load and reward and describe an unanticipated role for sweet taste in regulating carbohydrate metabolism, revealing a novel mechanism by which sugar-sweetened beverages influence physiological responses to carbohydrate ingestion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.