Evidence map›Paper›PMID 28802811›Full record

Trial reportArchives of physical medicine and rehabilitation2018

Effects of Respiratory Training on Heart Rate Variability and Baroreflex Sensitivity in Individuals With Chronic Spinal Cord Injury.

Bonnie E Legg Ditterline, Sevda C Aslan, David C Randall, Susan J Harkema, Camilo Castillo, Alexander V Ovechkin

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of physical medicine and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07504055 (Effectiveness of Transcutaneous Spinal Cord Stimulation on Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07504055 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Transcutaneous Spinal Cord Stimulation on Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury

TypeinterventionalSponsorUniversity of LouisvilleRan2026 to 2029Enrolled40ConditionsSpinal Cord Injury, Orthostatic Hypertension, Autonomic DysreflexiaArmsSpinal Cord Transcutaneous Stimulation
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Adaptive Sports in Spinal Cord Injury: a Systematic Review.Current physical medicine and rehabilitation reports · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bonnie E Legg DitterlineDepartment of Physiology, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
Sevda C AslanDepartment of Neurological Surgery, University of Louisville, Louisville, KY.
David C RandallDepartment of Physiology, University of Kentucky, Lexington, KY.
Susan J HarkemaDepartment of Physiology, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
Camilo CastilloDepartment of Neurological Surgery, University of Louisville, Louisville, KY.
Alexander V OvechkinDepartment of Physiology, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY. Electronic address: alexander.ovechkin@louisville.edu.
University of Louisville · USNeurological Surgery · USUniversity of Kentucky · US

Funding

Mechanisms of plasticity and repair after SCIP30GM103507 · NIGMS · UNIVERSITY OF LOUISVILLE · PI WHITTEMORE, SCOTT R · 2012 to 2015
$4.2M
Respiratory motor control and blood pressure regulation after spinal cord injuryR01HL103750 · NHLBI · UNIVERSITY OF LOUISVILLE · PI OVECHKIN, ALEXANDER VLADIMIROVICH · 2011 to 2014
$1.2M
NHLBI NIH HHS R01 HL103750NIGMS NIH HHS P30 GM103507
6 · The paper itself

Abstract

objectiveTo evaluate the effects of pressure threshold respiratory training (RT) on heart rate variability and baroreflex sensitivity in persons with chronic spinal cord injury (SCI).

designBefore-after intervention case-controlled clinical study.

settingSCI research center and outpatient rehabilitation unit.

participantsParticipants (N=44) consisted of persons with chronic SCI ranging from C2 to T11 who participated in RT (n=24), and untrained control subjects with chronic SCI ranging from C2 to T9 (n=20).

interventionsA total of 21±2 RT sessions performed 5 days a week during a 4-week period using a combination of pressure threshold inspiratory and expiratory devices.

main outcome measuresForced vital capacity (FVC), forced expiratory volume in 1 second (FEV

resultsIn contrast to the untrained controls, individuals in the RT group experienced significantly increased FVC and FEV

conclusionsInspiratory-expiratory pressure threshold RT is a promising technique to positively affect both respiratory and cardiovascular dysregulation observed in persons with chronic SCI.

Indexed as

AdultAutonomic Nervous SystemBaroreflexCase-Control StudiesChronic DiseaseFemaleForced Expiratory VolumeHeart RateHumansMaleMiddle AgedRespiratory MechanicsRespiratory TherapySpinal Cord InjuriesTreatment OutcomeVital CapacityAutonomic nervous systemBlood pressureBreathing exercisesHypotensionRehabilitationRespirationSpinal cord injuries

Identifiers

PMID28802811
PMCPMC5807237
OpenAlexW2743719069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.