Evidence map›Paper›PMID 28802636›Full record

ReviewAutonomic neuroscience : basic & clinical2017

Cardiac neuroanatomy - Imaging nerves to define functional control.

Peter Hanna, Pradeep S Rajendran, Olujimi A Ajijola, Marmar Vaseghi, J Andrew Armour, Jefrrey L Ardell, Kalyanam Shivkumar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Autonomic neuroscience : basic & clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
  2. Article
  3. Heart Meets Brain: Insights into Neurocardiac Pathophysiology.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  4. Article
  5. Review
  6. Review
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  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Mapping of Neuro-Cardiac Electrophysiology: Interlinking Epilepsy and Arrhythmia.Journal of cardiovascular development and disease · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter HannaUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Pradeep S RajendranUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Molecular, Cellular & Integrative Physiology Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Olujimi A AjijolaUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Marmar VaseghiUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
J Andrew ArmourUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Jefrrey L ArdellUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Molecular, Cellular & Integrative Physiology Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Kalyanam ShivkumarUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Molecular, Cellular & Integrative Physiology Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. Electronic address: kshivkumar@mednet.ucla.edu.

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
ELECTROPHYSIOLOGICAL EFFECTS OF NEURAL REMODELING OF THE VENTRICLESR01HL084261 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM · 2006 to 2016
$3.4M
Myocardial Ischemia Remodels the Cardiac Nervous SystemR01HL071830 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI ARDELL, JEFFREY L · 2005 to 2013
$2.8M
Cardiac Afferent Neurotransmission and Modulation of Ventricular Parasympathetic ControlDP2HL132356 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VASEGHI, MARMAR · 2015 to 2015
$2.3M
Antiarrhythmic Mechanisms of Bilateral Cardiac Sympathetic DecentralizationK08HL125730 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A · 2015 to 2019
$833k
Distributed electrode system for high-fidelity cardio-neural mappingU18EB021799 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2015 to 2017
$640k
Myocardial infarction alters information processing within the intrinsic cardiac nervous systemF31HL127974 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAJENDRAN, PRADEEP SUNDARAM · 2015 to 2017
$72k
NHLBI NIH HHS DP2 HL132356NHLBI NIH HHS F31 HL127974NHLBI NIH HHS K08 HL125730NHLBI NIH HHS L30 HL110282NHLBI NIH HHS L30 HL129238NHLBI NIH HHS R01 HL071830NHLBI NIH HHS R01 HL084261NHLBI NIH HHS T32 HL007895NIBIB NIH HHS U18 EB021799NIH HHS OT2 OD023848
6 · The paper itself

Abstract

The autonomic nervous system regulates normal cardiovascular function and plays a critical role in the pathophysiology of cardiovascular disease. Further understanding of the interplay between the autonomic nervous system and cardiovascular system holds promise for the development of neuroscience-based cardiovascular therapeutics. To this end, techniques to image myocardial innervation will help provide a basis for understanding the fundamental underpinnings of cardiac neural control. In this review, we detail the evolution of gross and microscopic anatomical studies for functional mapping of cardiac neuroanatomy.

Indexed as

Image Processing, Computer-AssistedNeuroanatomyAutonomic Nervous SystemCardiovascular DiseasesHeartHumansMotor NeuronsAutonomic nervous systemIntracardiac nervous systemMyocardial innervationNeurocardiology

Identifiers

PMID28802636
PMCPMC5680093

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.