ArticleTuberculosis (Edinburgh, Scotland)2017
The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.
Article in Tuberculosis (Edinburgh, Scotland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Airflow Determines Natural Airborne Transmission of Tuberculosis in a Guinea Pig Model.bioRxiv : the preprint server for biology · 2025Article
- Comparative anatomy of respiratory bronchioles and lobular structures in mammals.Journal of toxicologic pathology · 2025Review
- An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis.Vaccine · 2024Article
- Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals.Frontiers in immunology · 2024Review
- Mycobacterial Genetic Technologies for Probing the Host-Pathogen Microenvironment.Infection and immunity · 2023Review
- An experimental porcine model of invasive candidiasis.Intensive care medicine experimental · 2023Article
- Animal models for COVID-19 and tuberculosis.Frontiers in immunology · 2023Review
- Pan-genome association study ofFrontiers in microbiology · 2022Article
- Non-respiratory particles emitted by guinea pigs in airborne disease transmission experiments.Scientific reports · 2021Article
- Emergence of persistent tubercle bacilli.Nature microbiology · 2021Article
- One Size Fits All? Not inFrontiers in cellular and infection microbiology · 2021Review
- Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models.Disease models & mechanisms · 2020Review
- Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters.Clinical microbiology reviews · 2020Review
- Modelling the dynamics of tuberculosis lesions in a virtual lung: Role of the bronchial tree in endogenous reinfection.PLoS computational biology · 2020Article
- Establishment and Simulation of 3D Geometric Models of Mini-Pig and Sheep Knee Joints Using Finite Element Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Innate Immunomodulation in Food Animals: Evidence for Trained Immunity?Frontiers in immunology · 2020Review
- Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis.BioMed research international · 2020Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In endemic countries more than 20% of tuberculosis (TB) cases are in infants and children. Current animal models study TB during adulthood but animal models for infant TB are scarce. Here we propose that minipigs can be used as an animal model to study adult, adolescent and infant TB including natural transmission. In these studies, two-month old minipigs (representing infant age in humans) and six-month old minipigs (representing adolescence in humans) were infected via the aerosol route with hyper-virulent clinical strain W-Beijing Mycobacterium tuberculosis (Mtb) HN878 and were monitored for 11 or 36 weeks post-challenge, respectively. In the same studies, infected and unchallenged animals were housed together. Viable bacteria were recovered from pulmonary and thoracic lymph nodes from both -infected and their initially unchallenged natural contacts. Bacillary load, gross lesions and histopathology revealed similarities to the spectrum of disease observed in human TB. The study did not reach terminal end point, thus it was not possible to annotate definitive clinical symptoms of active TB. The results demonstrated that minipigs are experimental hosts of Mtb HN878, and the pathology developed in their lungs resembles pathological findings described in human TB. Importantly, within communities of Mtb infected minipigs natural transmission occurs.
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