ArticleBiomaterials2017
Flexible biodegradable citrate-based polymeric step-index optical fiber.
Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 107 citations in OpenAlex.
- Citrate polymer optical fiber for measuring refractive index based on LSPR sensor.Scientific reports · 2024Article
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Recent Insights about the Role of Gels in Organic Photonics and Electronics.Gels (Basel, Switzerland) · 2023Review
- Agar-based optical sensors for electric current measurements.Scientific reports · 2023Article
- A biodegradable, flexible photonic patch for in vivo phototherapy.Nature communications · 2023Article
- Citric Acid-Based Intrinsic Band-Shifting Photoluminescent Materials.Research (Washington, D.C.) · 2023Review
- A road map on synthetic strategies and applications of biodegradable polymers.Polymer bulletin (Berlin, Germany) · 2022Review
- Carboxymethyl Cellulose (CMC) Optical Fibers for Environment Sensing and Short-Range Optical Signal Transmission.ACS applied materials & interfaces · 2022Article
- Phototherapy and optical waveguides for the treatment of infection.Advanced drug delivery reviews · 2021Review
- Targeted optical fluorescence imaging: a meta-narrative review and future perspectives.European journal of nuclear medicine and molecular imaging · 2021Review
- Biocompatible and Biodegradable Polymer Optical Fiber for Biomedical Application: A Review.Biosensors · 2021Review
- Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021Review
- Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications.Materials (Basel, Switzerland) · 2021Review
- Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.Micromachines · 2020Review
- Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies.Sensors (Basel, Switzerland) · 2020Article
- Review
- Multifunctional materials for implantable and wearable photonic healthcare devices.Nature reviews. Materials · 2020Article
- Soft and Stretchable Polymeric Optical Waveguide-Based Sensors for Wearable and Biomedical Applications.Sensors (Basel, Switzerland) · 2019Review
- Enabling biodegradable functional biomaterials for the management of neurological disorders.Advanced drug delivery reviews · 2019Review
- Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature.Science advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechano-biological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step-index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed. Furthermore, we developed a two-step fabrication method to fabricate flexible and low-loss (0.4 db/cm) optical fibers, and performed systematic characterizations to study optical, spectroscopic, mechanical, and biodegradable properties. In addition, we demonstrated the proof of concept of image transmission through the citrate-based polymeric optical fibers and conducted in vivo deep tissue light delivery and fluorescence sensing in a Sprague-Dawley (SD) rat, laying the groundwork for realizing future implantable devices for long-term implantation where deep-tissue light delivery, sensing and imaging are desired, such as cell, tissue, and scaffold imaging in regenerative medicine and in vivo optogenetic stimulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.