ArticleCell2017
orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants.
Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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Who cites it
130 citing papers in PubMed, 302 citations in OpenAlex.
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Beat- and Side-family cell-surface molecules are expressed combinatorially in the partner neurons of the olfactory circuit in Drosophila.PLoS biology · 2026Article
- Chemical and microbial regulators of foraging behaviors in subterranean termites.Pest management science · 2026Review
- Adaptive evolution of odorant receptors is associated with elaborations of social organization in ants.Molecular biology and evolution · 2026Article
- Pheromone-Mediated Social Organization and Pest Management of the Red Imported Fire Ant,Insects · 2026Review
- Comparative analysis of 163 ant genomes reveals recurrent horizontal gene transfer from bacteria to ants.GigaScience · 2026Article
- Influences of pupal presence and worker number on the survival and development of pharaoh ant (Animal cells and systems · 2026Article
- Distribution and efficacy of ingested dsRNA targeting tissue-specific genes in the Argentine ant, Linepithema humile.PloS one · 2026Article
- Sensitivity to cuticular hydrocarbons across the odorant receptor family in the Indian jumping ant,Frontiers in insect science · 2026Article
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- Chemosensation drives divergent social behavior in Drosophila.Communications biology · 2025Article
- Unveiling the developmental dynamics and functional role of Odorant Receptor Co-receptor (Orco) in Aedes albopictus: A novel mechanism for regulating odorant receptor expression.PLoS neglected tropical diseases · 2025Article
- Transcriptional interference gates monogenic odorant receptor expression in ants.Current biology : CB · 2025Article
- Identification and Stereoselective Total Synthesis of an Insect Homosesquiterpene from the Clonal Raider AntJournal of natural products · 2025Article
- Caste- and environment-associated differential expression of olfactory receptors in pest ants.Scientific reports · 2025Article
- Transcriptional Interference Gates Monogenic Odorant Receptor Expression in Ants.bioRxiv : the preprint server for biology · 2025Article
- Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy.eLife · 2025Article
- Article
- Developmental transcriptomics inGenome research · 2025Article
- Refined CRISPR/Cas9 genome editing in the pea aphid uncovers the essential roles of Laccase2 in overwintering egg adaptation.PLoS genetics · 2025Article
70 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 1 country.
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Abstract
Life inside ant colonies is orchestrated with diverse pheromones, but it is not clear how ants perceive these social signals. It has been proposed that pheromone perception in ants evolved via expansions in the numbers of odorant receptors (ORs) and antennal lobe glomeruli. Here, we generate the first mutant lines in the clonal raider ant, Ooceraea biroi, by disrupting orco, a gene required for the function of all ORs. We find that orco mutants exhibit severe deficiencies in social behavior and fitness, suggesting they are unable to perceive pheromones. Surprisingly, unlike in Drosophila melanogaster, orco mutant ants also lack most of the ∼500 antennal lobe glomeruli found in wild-type ants. These results illustrate that ORs are essential for ant social organization and raise the possibility that, similar to mammals, receptor function is required for the development and/or maintenance of the highly complex olfactory processing areas in the ant brain. VIDEO ABSTRACT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.